AFREZZA (REGULAR INSULIN) 4 UNIT CARTRIDGE
For 1 unit (EA)
Pharmacies pay
$5.21 filed
1 × $5.20552 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$8.98 filed
1 × $8.98197 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
1.7× estimated
Medicare paid 1.7× what pharmacies pay.
Part D averages every strength and form sold under “Afrezza” / “Insulin Regular, Human” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$10.99 estimated
$5.21 + $0.78 (15%) + $5.00 fee per fill = $10.99
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
AFREZZA (REGULAR INSULIN) 4 UNIT CARTRIDGE is how the CMS NADAC file names this product. The FDA NDC Directory lists it as insulin human, under the trade name “AFREZZA”.
FDA gives its dosage form as powder, metered and its route as respiratory (inhalation).
The labeler, the company named on the label, is Mannkind Corporation.
FDA’s Established Pharmacologic Class for it is Insulin.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 47918-0874-90.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $5.21 for 1 unit (EA) (1 × $5.20552 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.
What NADAC measures · NADAC explanation codes
The NDC
- 47918-0874-90 · Mannkind Corporation · $5.20552 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
11 other products in the NADAC file share the FDA nonproprietary name insulin human with AFREZZA (REGULAR INSULIN) 4 UNIT CARTRIDGE.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| AFREZZA ((REGULAR INSULIN) 8 UNIT CARTRIDGE | $10.3754 per EA filed | $8.98197 per EA filed |
| AFREZZA (REGULAR INSULIN) 4 UNIT CARTRIDGE this page | $5.20552 per EA filed | $8.98197 per EA filed |
| AFREZZA (REGULAR INSULIN) 12 UNIT CARTRIDGE | $15.65297 per EA filed | $8.98197 per EA filed |
| AFREZZA (REGULAR INSULIN) 60-4 UNIT/60-8 UNIT/60-12 UNIT | $10.33288 per EA filed | $8.98197 per EA filed |
| AFREZZA (REGULAR INSULIN) 90-4 UNIT / 90-8 UNIT | $7.78053 per EA filed | $8.98197 per EA filed |
| AFREZZA (REGULAR INSULIN) 90-8 UNIT / 90-12 UNIT | $13.03769 per EA filed | $8.98197 per EA filed |
| HUMULIN 70-30 VIAL | $4.25636 per ML filed | We don’t know yet |
| HUMULIN 70/30 KWIKPEN | $9.0349 per ML filed | We don’t know yet |
| HUMULIN N 100 UNIT/ML KWIKPEN | $9.03325 per ML filed | $6.74415 per ML filed |
| HUMULIN N 100 UNIT/ML VIAL | $4.26742 per ML filed | $3.79166 per ML filed |
| HUMULIN R 100 UNIT/ML VIAL | $4.2629 per ML filed | $4.00953 per ML filed |
| HUMULIN R 500 UNIT/ML KWIKPEN | $91.60736 per ML filed | We don’t know yet |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-01, 2026-05-20, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
What Medicare paid
Medicare Part D paid $8.98 for 1 unit (EA), at an average of $8.98197 per EA in 2024 (2024-01-01 to 2024-12-31) for “Afrezza” and “Insulin Regular, Human”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 13,165 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 unit (EA)? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for AFREZZA (REGULAR INSULIN) 4 UNIT CARTRIDGE labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Afrezza / Insulin Regular, Human: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on brand name.
- Why does this page start at 1 unit (EA)?
- NADAC prices this product per EA, and the FDA NDC Directory lists its NDC as dosage form “POWDER, METERED” with route “RESPIRATORY (INHALATION)”. Only a tablet, capsule, lozenge or troche with route “ORAL”, or a tablet or film with route “SUBLINGUAL” or “BUCCAL”, starts at 30, and this is not one. NADAC’s EA for it may be a whole package (such as a kit, pen, syringe, vial or inhaler) or one dose inside it, and the files do not say which. So the card starts at 1 unit (EA) rather than guess how many make up a fill; change it to match your prescription.