OpenBilldrug price receipt

NADAC week of 2026-10-14

ALPRAZOLAM 0.25 MG TABLET

For 30 tablets

Pharmacies pay

$0.71 filed

30 × $0.02356 per EA

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D paid

$2.74 filed

30 × $0.09146 per EA, Part D average

Medicare's price is not your price.

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18


The spread

3.9× estimated

Medicare paid 3.9× what pharmacies pay.

Part D averages every strength and form sold under “Alprazolam” into one figure, so it is not specific to this NDC.

OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)

Cost-plus estimate

$5.82 estimated

$0.71 + $0.11 (15%) + $5.00 fee per fill = $5.82

This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out

OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)

Open the interactive card Change the quantity, type what you were charged, and see every record in full.

What it is

ALPRAZOLAM 0.25 MG TABLET is how the CMS NADAC file names this product. The FDA NDC Directory lists it as alprazolam.

FDA gives its dosage form as tablet and its route as oral.

FDA lists 7 labelers (the companies named on the label) for its NDCs, among them Actavis Pharma, Inc., Sandoz Inc and AvPAK.

FDA’s Established Pharmacologic Class for it is Benzodiazepine.

The NADAC file of 2026-10-14 prices it under 18 NDCs (National Drug Codes); the FDA directory lists 16 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $0.71 for 30 tablets (30 × $0.02356 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

The 7 labelers

LabelerNDCsPharmacies pay per unit
Actavis Pharma, Inc.3$0.02356 per EA filed
Aurobindo Pharma Limited3$0.02356 per EA filed
Mylan Pharmaceuticals Inc.3$0.02356 per EA filed
Sandoz Inc3$0.02356 per EA filed
Natco Pharma USA LLC2$0.02356 per EA filed
American Health Packaging1$0.02356 per EA filed
AvPAK1$0.02356 per EA filed
Not listed as a package in the FDA directory2$0.02356 per EA filed
All 18 NDCs, with labeler and price
  • 00228-2027-10 · Actavis Pharma, Inc. · $0.02356 per EA · eff. 2026-09-23 filed
  • 00228-2027-50 · Actavis Pharma, Inc. · $0.02356 per EA · eff. 2026-09-23 filed
  • 00228-2027-96 · Actavis Pharma, Inc. · $0.02356 per EA · eff. 2026-09-23 filed
  • 00781-1061-01 · Sandoz Inc · $0.02356 per EA · eff. 2026-09-23 filed
  • 00781-1061-05 · Sandoz Inc · $0.02356 per EA · eff. 2026-09-23 filed
  • 00781-1061-10 · Sandoz Inc · $0.02356 per EA · eff. 2026-09-23 filed
  • 50268-0033-11 · not listed as a package in the FDA directory · $0.02356 per EA · eff. 2026-09-23 filed
  • 50268-0033-15 · AvPAK · $0.02356 per EA · eff. 2026-09-23 filed
  • 59762-3719-01 · Mylan Pharmaceuticals Inc. · $0.02356 per EA · eff. 2026-09-23 filed
  • 59762-3719-03 · Mylan Pharmaceuticals Inc. · $0.02356 per EA · eff. 2026-09-23 filed
  • 59762-3719-04 · Mylan Pharmaceuticals Inc. · $0.02356 per EA · eff. 2026-09-23 filed
  • 60687-0377-01 · American Health Packaging · $0.02356 per EA · eff. 2026-09-23 filed
  • 60687-0377-11 · not listed as a package in the FDA directory · $0.02356 per EA · eff. 2026-09-23 filed
  • 65862-0676-01 · Aurobindo Pharma Limited · $0.02356 per EA · eff. 2026-09-23 filed
  • 65862-0676-05 · Aurobindo Pharma Limited · $0.02356 per EA · eff. 2026-09-23 filed
  • 65862-0676-99 · Aurobindo Pharma Limited · $0.02356 per EA · eff. 2026-09-23 filed
  • 69339-0199-05 · Natco Pharma USA LLC · $0.02356 per EA · eff. 2026-09-23 filed
  • 69339-0199-10 · Natco Pharma USA LLC · $0.02356 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

19 other products in the NADAC file share the FDA nonproprietary name alprazolam with ALPRAZOLAM 0.25 MG TABLET.

ProductPharmacies pay per unitMedicare per unit
ALPRAZOLAM 0.25 MG TABLET this page
generic · tablet
$0.02356 per EA filed
eff. 2026-09-23
$0.09146 per EA filed
Part D 2024 average
ALPRAZOLAM 0.5 MG TABLET
generic · tablet
$0.02245 per EA filed
eff. 2026-09-23
$0.09146 per EA filed
Part D 2024 average
ALPRAZOLAM 1 MG TABLET
generic · tablet
$0.02433 per EA filed
eff. 2026-09-23
$0.09146 per EA filed
Part D 2024 average
ALPRAZOLAM 2 MG TABLET
generic · tablet
$0.04877 per EA filed
eff. 2026-09-23
$0.09146 per EA filed
Part D 2024 average
ALPRAZOLAM ER 0.5 MG TABLET
generic · tablet, extended release
$0.15333 per EA filed
eff. 2026-09-23
$0.70412 per EA filed
Part D 2024 average
ALPRAZOLAM ER 1 MG TABLET
generic · tablet, extended release
$0.15598 per EA filed
eff. 2026-09-23
$0.70412 per EA filed
Part D 2024 average
ALPRAZOLAM ER 2 MG TABLET
generic · tablet, extended release
$0.20607 per EA filed
eff. 2026-09-23
$0.70412 per EA filed
Part D 2024 average
ALPRAZOLAM ER 3 MG TABLET
generic · tablet, extended release
$0.26176 per EA filed
eff. 2026-09-23
$0.70412 per EA filed
Part D 2024 average
ALPRAZOLAM INTENSOL 1 MG/ML
generic · solution, concentrate
$2.869 per ML filed
eff. 2025-10-22
We don’t know yet
ALPRAZOLAM ODT 0.25 MG TAB
generic · tablet, orally disintegrating
$0.96967 per EA filed
eff. 2026-09-23
$1.20825 per EA filed
Part D 2024 average
ALPRAZOLAM ODT 0.5 MG TAB
generic · tablet, orally disintegrating
$1.23092 per EA filed
eff. 2026-09-23
$1.20825 per EA filed
Part D 2024 average
ALPRAZOLAM ODT 1 MG TAB
generic · tablet, orally disintegrating
$1.77 per EA filed
eff. 2026-09-23
$1.20825 per EA filed
Part D 2024 average
ALPRAZOLAM XR 0.5 MG TABLET
generic · tablet, extended release
$0.15333 per EA filed
eff. 2026-09-23
$0.627 per EA filed
Part D 2024 average
ALPRAZOLAM XR 1 MG TABLET
generic · tablet, extended release
$0.15598 per EA filed
eff. 2026-09-23
$0.627 per EA filed
Part D 2024 average
ALPRAZOLAM XR 2 MG TABLET
generic · tablet, extended release
$0.20607 per EA filed
eff. 2026-09-23
$0.627 per EA filed
Part D 2024 average
ALPRAZOLAM XR 3 MG TABLET
generic · tablet, extended release
$0.26176 per EA filed
eff. 2026-09-23
$0.627 per EA filed
Part D 2024 average
XANAX 0.25 MG TABLET
brand · tablet
$5.62948 per EA filed
eff. 2026-09-23
$7.77667 per EA filed
Part D 2024 average
XANAX 0.5 MG TABLET
brand · tablet
$7.03342 per EA filed
eff. 2026-09-23
$7.77667 per EA filed
Part D 2024 average
XANAX 1 MG TABLET
brand · tablet
$9.35465 per EA filed
eff. 2026-09-23
$7.77667 per EA filed
Part D 2024 average
XANAX 2 MG TABLET
brand · tablet
$15.90988 per EA filed
eff. 2026-09-23
$7.77667 per EA filed
Part D 2024 average

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2025-10-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 18 NDCs’ NADAC prices is $0.02356 per EA filed.

Of the 76 other products in FDA’s Benzodiazepine class priced per EA, 73 have a higher middle NADAC price and 3 a lower one. The one in the middle is CLONAZEPAM 1 MG ODT, at $0.56689 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

What Medicare paid

Medicare Part D paid $2.74 for 30 tablets, at an average of $0.09146 per EA in 2024 (2024-01-01 to 2024-12-31) for “Alprazolam”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 11,609,703 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

Questions

Why is the comparison with Medicare for ALPRAZOLAM 0.25 MG TABLET labelled estimated?
Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Alprazolam / Alprazolam: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name.