AMITRIPTYLINE HCL 50 MG TAB
For 30 tablets
Pharmacies pay
$2.89 filed
30 × $0.09628 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$6.56 filed
30 × $0.21864 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
2.3× estimated
Medicare paid 2.3× what pharmacies pay.
Part D averages every strength and form sold under “Amitriptyline HCl” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$8.32 estimated
$2.89 + $0.43 (15%) + $5.00 fee per fill = $8.32
This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
AMITRIPTYLINE HCL 50 MG TAB is how the CMS NADAC file names this product. The FDA NDC Directory lists it as amitriptyline hydrochloride.
FDA gives its dosage form as “tablet, film coated”, “tablet” and “tablet, coated” and its route as oral.
FDA lists 13 labelers (the companies named on the label) for its NDCs, among them Sandoz Inc, Major Pharmaceuticals and AiPing Pharmaceutical, Inc.
FDA’s Established Pharmacologic Class for it is Tricyclic Antidepressant.
The NADAC file of 2026-10-14 prices it under 25 NDCs (National Drug Codes); the FDA directory lists 23 of them.
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $2.89 for 30 tablets (30 × $0.09628 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.
What NADAC measures · Why 30 tablets · NADAC explanation codes
The 13 labelers
| Labeler | NDCs | Pharmacies pay per unit |
|---|---|---|
| Advagen Pharma Ltd | 2 | $0.09628 per EA filed |
| AiPing Pharmaceutical, Inc. | 2 | $0.09628 per EA filed |
| Lifestar Pharma LLC | 2 | $0.09628 per EA filed |
| Northstar Rx LLC. | 2 | $0.09628 per EA filed |
| Rising Pharma Holdings, Inc. | 2 | $0.09628 per EA filed |
| Sandoz Inc | 2 | $0.09628 per EA filed |
| Sun Pharmaceutical Industries, Inc. | 2 | $0.09628 per EA filed |
| Unichem Pharmaceuticals (USA), Inc. | 2 | $0.09628 per EA filed |
| Westminster Pharmaceuticals, LLC | 2 | $0.09628 per EA filed |
| Zydus Pharmaceuticals USA Inc. | 2 | $0.09628 per EA filed |
| American Health Packaging | 1 | $0.09628 per EA filed |
| AvPAK | 1 | $0.09628 per EA filed |
| Major Pharmaceuticals | 1 | $0.09628 per EA filed |
| Not listed as a package in the FDA directory | 2 | $0.09628 per EA filed |
All 25 NDCs, with labeler and price
- 00781-1488-01 · Sandoz Inc · $0.09628 per EA · eff. 2026-09-23 filed
- 00781-1488-10 · Sandoz Inc · $0.09628 per EA · eff. 2026-09-23 filed
- 00904-7411-61 · Major Pharmaceuticals · $0.09628 per EA · eff. 2026-09-23 filed
- 11788-0079-01 · AiPing Pharmaceutical, Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 11788-0079-10 · AiPing Pharmaceutical, Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 16571-0107-01 · Rising Pharma Holdings, Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 16571-0107-10 · Rising Pharma Holdings, Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 16714-0259-01 · Northstar Rx LLC. · $0.09628 per EA · eff. 2026-09-23 filed
- 16714-0259-02 · Northstar Rx LLC. · $0.09628 per EA · eff. 2026-09-23 filed
- 29300-0421-01 · Unichem Pharmaceuticals (USA), Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 29300-0421-10 · Unichem Pharmaceuticals (USA), Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 50268-0039-11 · not listed as a package in the FDA directory · $0.09628 per EA · eff. 2026-09-23 filed
- 50268-0039-15 · AvPAK · $0.09628 per EA · eff. 2026-09-23 filed
- 57664-0689-18 · Sun Pharmaceutical Industries, Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 57664-0689-88 · Sun Pharmaceutical Industries, Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 60687-0444-01 · American Health Packaging · $0.09628 per EA · eff. 2026-09-23 filed
- 60687-0444-11 · not listed as a package in the FDA directory · $0.09628 per EA · eff. 2026-09-23 filed
- 69367-0390-01 · Westminster Pharmaceuticals, LLC · $0.09628 per EA · eff. 2026-09-23 filed
- 69367-0390-10 · Westminster Pharmaceuticals, LLC · $0.09628 per EA · eff. 2026-09-23 filed
- 70710-1227-00 · Zydus Pharmaceuticals USA Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 70710-1227-01 · Zydus Pharmaceuticals USA Inc. · $0.09628 per EA · eff. 2026-09-23 filed
- 70756-0203-11 · Lifestar Pharma LLC · $0.09628 per EA · eff. 2026-09-23 filed
- 70756-0203-12 · Lifestar Pharma LLC · $0.09628 per EA · eff. 2026-09-23 filed
- 72888-0069-00 · Advagen Pharma Ltd · $0.09628 per EA · eff. 2026-09-23 filed
- 72888-0069-01 · Advagen Pharma Ltd · $0.09628 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
5 other products in the NADAC file share the FDA nonproprietary name amitriptyline hydrochloride with AMITRIPTYLINE HCL 50 MG TAB.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| AMITRIPTYLINE HCL 10 MG TAB | $0.02998 per EA filed | $0.21864 per EA filed |
| AMITRIPTYLINE HCL 25 MG TAB | $0.05221 per EA filed | $0.21864 per EA filed |
| AMITRIPTYLINE HCL 50 MG TAB this page | $0.09628 per EA filed | $0.21864 per EA filed |
| AMITRIPTYLINE HCL 75 MG TAB | $0.1225 per EA filed | $0.21864 per EA filed |
| AMITRIPTYLINE HCL 100 MG TAB | $0.14274 per EA filed | $0.21864 per EA filed |
| AMITRIPTYLINE HCL 150 MG TAB | $0.28986 per EA filed | $0.21864 per EA filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
The middle of its 25 NDCs’ NADAC prices is $0.09628 per EA filed.
Of the 34 other products in FDA’s Tricyclic Antidepressant class priced per EA, 29 have a higher middle NADAC price and 5 a lower one. The one in the middle is NORTRIPTYLINE HCL 50 MG CAP, at $0.20739 per EA filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $6.56 for 30 tablets, at an average of $0.21864 per EA in 2024 (2024-01-01 to 2024-12-31) for “Amitriptyline HCl”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 3,704,512 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for AMITRIPTYLINE HCL 50 MG TAB labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Amitriptyline HCl / Amitriptyline HCl: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name.
Related pages
Its pharmacologic class
Related in the same class
- NORTRIPTYLINE HCL 10 MG CAP
- DOXEPIN HCL 3 MG TABLET
- IMIPRAMINE HCL 10 MG TABLET
- CLOMIPRAMINE 25 MG CAPSULE
- DESIPRAMINE 10 MG TABLET