BISOPROLOL-HYDROCHLOROTHIAZIDE 2.5-6.25 MG TB
For 30 tablets
Pharmacies pay
$6.40 filed
30 × $0.21329 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$10.29 filed
30 × $0.34294 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
1.6× estimated
Medicare paid 1.6× what pharmacies pay.
Part D averages every strength and form sold under “Bisoprolol-Hydrochlorothiazide” / “Bisoprolol/Hydrochlorothiazide” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$12.36 estimated
$6.40 + $0.96 (15%) + $5.00 fee per fill = $12.36
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
BISOPROLOL-HYDROCHLOROTHIAZIDE 2.5-6.25 MG TB is how the CMS NADAC file names this product. The FDA NDC Directory lists it as bisoprolol fumarate and hydrochlorothiazide.
FDA gives its dosage form as “tablet, film coated” and “tablet” and its route as oral.
FDA lists 7 labelers (the companies named on the label) for its NDCs, among them Teva Pharmaceuticals USA, Inc., Mylan Pharmaceuticals Inc. and Unichem Pharmaceuticals (USA), Inc.
FDA lists it under 2 Established Pharmacologic Classes: beta-Adrenergic Blocker and Thiazide Diuretic.
The NADAC file of 2026-10-14 prices it under 15 NDCs (National Drug Codes).
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $6.40 for 30 tablets (30 × $0.21329 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.
What NADAC measures · Why 30 tablets · NADAC explanation codes
The 7 labelers
| Labeler | NDCs | Pharmacies pay per unit |
|---|---|---|
| Edenbridge Pharmaceuticals LLC. | 3 | $0.21329 per EA filed |
| GLENMARK PHARMACEUTICALS INC., USA | 3 | $0.21329 per EA filed |
| Unichem Pharmaceuticals (USA), Inc. | 3 | $0.21329 per EA filed |
| Viona Pharmaceuticals Inc | 3 | $0.21329 per EA filed |
| ANI Pharmaceuticals, Inc. | 1 | $0.21329 per EA filed |
| Mylan Pharmaceuticals Inc. | 1 | $0.21329 per EA filed |
| Teva Pharmaceuticals USA, Inc. | 1 | $0.21329 per EA filed |
All 15 NDCs, with labeler and price
- 00093-3241-01 · Teva Pharmaceuticals USA, Inc. · $0.21329 per EA · eff. 2026-09-23 filed
- 00378-0501-01 · Mylan Pharmaceuticals Inc. · $0.21329 per EA · eff. 2026-09-23 filed
- 29300-0187-01 · Unichem Pharmaceuticals (USA), Inc. · $0.21329 per EA · eff. 2026-09-23 filed
- 29300-0187-05 · Unichem Pharmaceuticals (USA), Inc. · $0.21329 per EA · eff. 2026-09-23 filed
- 29300-0187-13 · Unichem Pharmaceuticals (USA), Inc. · $0.21329 per EA · eff. 2026-09-23 filed
- 42799-0920-01 · Edenbridge Pharmaceuticals LLC. · $0.21329 per EA · eff. 2026-09-23 filed
- 42799-0920-02 · Edenbridge Pharmaceuticals LLC. · $0.21329 per EA · eff. 2026-09-23 filed
- 42799-0920-30 · Edenbridge Pharmaceuticals LLC. · $0.21329 per EA · eff. 2026-09-23 filed
- 68462-0878-01 · GLENMARK PHARMACEUTICALS INC., USA · $0.21329 per EA · eff. 2026-09-23 filed
- 68462-0878-05 · GLENMARK PHARMACEUTICALS INC., USA · $0.21329 per EA · eff. 2026-09-23 filed
- 68462-0878-30 · GLENMARK PHARMACEUTICALS INC., USA · $0.21329 per EA · eff. 2026-09-23 filed
- 70954-0412-30 · ANI Pharmaceuticals, Inc. · $0.21329 per EA · eff. 2026-09-23 filed
- 72578-0113-01 · Viona Pharmaceuticals Inc · $0.21329 per EA · eff. 2026-09-23 filed
- 72578-0113-05 · Viona Pharmaceuticals Inc · $0.21329 per EA · eff. 2026-09-23 filed
- 72578-0113-06 · Viona Pharmaceuticals Inc · $0.21329 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
2 other products in the NADAC file share the FDA nonproprietary name bisoprolol fumarate and hydrochlorothiazide with BISOPROLOL-HYDROCHLOROTHIAZIDE 2.5-6.25 MG TB.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| BISOPROLOL-HYDROCHLOROTHIAZIDE 2.5-6.25 MG TB this page | $0.21329 per EA filed | $0.34294 per EA filed |
| BISOPROLOL-HYDROCHLOROTHIAZIDE 5-6.25 MG TAB | $0.22026 per EA filed | $0.34294 per EA filed |
| BISOPROLOL-HYDROCHLOROTHIAZIDE 10-6.25 MG TAB | $0.20936 per EA filed | $0.34294 per EA filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
The middle of its 15 NDCs’ NADAC prices is $0.21329 per EA filed.
Of the 76 other products in FDA’s beta-Adrenergic Blocker class priced per EA, 42 have a higher middle NADAC price and 34 a lower one. The one in the middle is NADOLOL 40 MG TABLET, at $0.26544 per EA filed (eff. 2026-09-23).
Of the 68 other products in FDA’s Thiazide Diuretic class priced per EA, 43 have a higher middle NADAC price and 25 a lower one. The one in the middle is AMILORIDE HCL-HYDROCHLOROTHIAZIDE 5-50 MG TAB, at $0.44985 per EA filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $10.29 for 30 tablets, at an average of $0.34294 per EA in 2024 (2024-01-01 to 2024-12-31) for “Bisoprolol-Hydrochlorothiazide” and “Bisoprolol/Hydrochlorothiazide”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 568,266 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for BISOPROLOL-HYDROCHLOROTHIAZIDE 2.5-6.25 MG TB labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Bisoprolol-Hydrochlorothiazide / Bisoprolol/Hydrochlorothiazide: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name.
Related pages
Its pharmacologic classes
Related in the same class
- METOPROLOL-HYDROCHLOROTHIAZIDE 100-25 MG TAB
- METOPROLOL SUCC ER 100 MG TAB
- HYDROCHLOROTHIAZIDE 12.5 MG TB
- METOPROLOL TARTRATE 100 MG TAB
- CARVEDILOL 12.5 MG TABLET