Why is the comparison with Medicare for BUTORPHANOL 10 MG/ML SPRAY labelled estimated?

Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Butorphanol Tartrate* / Butorphanol Tartrate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. All 2 NADAC NDCs the name join matched to it have an FDA route including NASAL.

Why does this page start at 2.5 mL?

NADAC prices this product per ML. The FDA NDC Directory’s package description gives 2.5 mL in one package for all 2 NDCs of this product (“1 BOTTLE, SPRAY in 1 CONTAINER (0054-3090-36) / 2.5 mL in 1 BOTTLE, SPRAY”), so the card starts at one package: 2.5 ML. Change it to match your prescription.

BUTORPHANOL 10 MG/ML SPRAY

For 2.5 mL

Pharmacies pay

$38.65 filed

2.5 × $15.45983 per ML

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D paid

$37.77 filed

2.5 × $15.10755 per ML, Part D average

Medicare's price is not your price.

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

The spread

0.98× estimated

Medicare paid about what pharmacies pay.

Part D averages every strength and form sold under “Butorphanol Tartrate*” / “Butorphanol Tartrate” into one figure, so it is not specific to this NDC.

OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)

Cost-plus estimate

$49.45 estimated

$38.65 + $5.80 (15%) + $5.00 fee per fill = $49.45

This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out

OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)

Open the interactive card Change the quantity, type what you were charged, and see every record in full.

What it is

BUTORPHANOL 10 MG/ML SPRAY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as butorphanol tartrate.

FDA gives its dosage form as “spray, metered” and “spray” and its route as nasal.

Its labelers, the companies named on the label, are Hikma Pharmaceuticals USA Inc. and Apotex Corp.

FDA’s Established Pharmacologic Class for it is Opioid Agonist/Antagonist.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $38.65 for 2.5 mL (2.5 × $15.45983 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 2 NDCs

00054-3090-36 · Hikma Pharmaceuticals USA Inc. · $15.45983 per ML · eff. 2026-09-23 filed
60505-0813-01 · Apotex Corp. · $15.45983 per ML · eff. 2026-09-23 filed

What Medicare paid

Medicare Part D paid $37.77 for 2.5 mL, at an average of $15.10755 per ML in 2024 (2024-01-01 to 2024-12-31) for “Butorphanol Tartrate*” and “Butorphanol Tartrate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 24,382 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

What is your cash price for 2.5 mL? Is it lower than what I would pay through my insurance?
How much is in the package I am getting? This page uses 2.5 mL; your package may hold a different amount.
If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.

Questions

Why is the comparison with Medicare for BUTORPHANOL 10 MG/ML SPRAY labelled estimated?: Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Butorphanol Tartrate* / Butorphanol Tartrate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. All 2 NADAC NDCs the name join matched to it have an FDA route including NASAL.
Why does this page start at 2.5 mL?: NADAC prices this product per ML. The FDA NDC Directory’s package description gives 2.5 mL in one package for all 2 NDCs of this product (“1 BOTTLE, SPRAY in 1 CONTAINER (0054-3090-36) / 2.5 mL in 1 BOTTLE, SPRAY”), so the card starts at one package: 2.5 ML. Change it to match your prescription.

Its pharmacologic class

Opioid Agonist/Antagonist 2 products

Related in the same class

NALBUPHINE 10 MG/ML AMPUL