DEPO-ESTRADIOL 5 MG/ML VIAL

What it is

DEPO-ESTRADIOL 5 MG/ML VIAL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as estradiol cypionate, under the trade name “Depo-Estradiol”.

FDA gives its dosage form as injection and its route as intramuscular.

The labeler, the company named on the label, is Pharmacia & Upjohn Company LLC.

FDA’s Established Pharmacologic Class for it is Estrogen.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00009-0271-01.

NADAC classes it in its brand rate-setting class B-ANDA, and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $259.54 for 5 mL (5 × $51.90841 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-07-01. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 2, the latest survey was within 2% of the current NADAC, so the NADAC was carried forward from the previous file; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

This NDC’s NADAC was carried forward from an earlier file (NADAC explanation code 2 or 4), not newly surveyed: it took effect on 2026-07-01. The file is new; the price is not.

What NADAC measures · NADAC explanation codes · Carried-forward prices

The NDC

• 00009-0271-01 · Pharmacia & Upjohn Company LLC · $51.90841 per ML · eff. 2026-07-01 filed carried forward

Compared with its class

Its NADAC price is $51.90841 per ML filed.

Of the 6 other products in FDA’s Estrogen class priced per ML, 0 have a higher middle NADAC price and 6 a lower one. The one in the middle is ESTRADIOL VALERATE 100 MG/5 ML, at $22.64523 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-07-01, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $186.98 for 5 mL, at an average of $37.39514 per ML in 2024 (2024-01-01 to 2024-12-31) for “Depo-Estradiol” and “Estradiol Cypionate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 3,076 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 5 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 5 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.