DIFLUPREDNATE 0.05% EYE DROP

What it is

DIFLUPREDNATE 0.05% EYE DROP is how the CMS NADAC file names this product. The FDA NDC Directory lists it as “difluprednate” and “difluprednate ophthalmic”, as its NDCs’ listings variously write the nonproprietary name, under the trade name “Difluprednate Ophthalmic Emulsion”.

FDA gives its dosage form as emulsion and its route as ophthalmic.

FDA lists 7 labelers (the companies named on the label) for its NDCs, among them Mylan Pharmaceuticals Inc., Sandoz Inc and Upsher-Smith Laboratories, LLC.

FDA lists no Established Pharmacologic Class for it.

The NADAC file of 2026-10-14 prices it under 8 NDCs (National Drug Codes); the FDA directory lists 7 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $48.43 for 5 mL (5 × $9.68661 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

The 7 labelers

Other strengths, forms and brands

1 other product in the NADAC file shares an FDA nonproprietary name with DIFLUPREDNATE 0.05% EYE DROP.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

What Medicare paid

Medicare Part D paid $95.01 for 5 mL, at an average of $19.00232 per ML in 2024 (2024-01-01 to 2024-12-31) for “Difluprednate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 131,416 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 5 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 5 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.