Why is the comparison with Medicare for DIHYDROERGOTAMINE 4 MG/ML SPRY labelled estimated?

Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Dihydroergotamine Mesylate* / Dihydroergotamine Mesylate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. Only NADAC NDCs whose FDA route includes NASAL point at this name (8 of the 10 the name join matched); NDCs of another route or with no known FDA route do not. 3 of the 8 NDCs that point at this name are not listed in the FDA NDC Directory as packages of their own; their route was taken from FDA's record for the same product (labeler and product code).

Why does this page start at 8 mL?

NADAC prices this product per ML. The FDA NDC Directory’s package description gives 8 mL in one package for the 1 of this product’s 2 NDCs it lists (“8 CARTON in 1 KIT (70069-880-08) / 1 VIAL in 1 CARTON (70069-880-01) / 1 mL in 1 VIAL”), so the card starts at one package: 8 ML. Change it to match your prescription.

DIHYDROERGOTAMINE 4 MG/ML SPRY

For 8 mL

Pharmacies pay

$235.48 – $397.04 filed

8 × $29.43546 to $49.63034 per ML (the 2 NDCs differ)

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D paid

$1,195.65 filed

8 × $149.45629 per ML, Part D average

Medicare's price is not your price.

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

The spread

3.0× – 5.1× estimated

Medicare paid between 3.0× and 5.1× what pharmacies pay, depending on the NDC.

Part D averages every strength and form sold under “Dihydroergotamine Mesylate*” / “Dihydroergotamine Mesylate” into one figure, so it is not specific to this NDC.

OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)

Cost-plus estimate

$275.80 – $461.60 estimated

NADAC for the pack + 15% + $5.00 fee per fill

This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out

OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)

Open the interactive card Change the quantity, type what you were charged, and see every record in full.

What it is

DIHYDROERGOTAMINE 4 MG/ML SPRY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as dihydroergotamine mesylate.

FDA gives its dosage form as spray, metered and its route as nasal.

The labeler, the company named on the label, is Somerset Therapeutics, LLC.

FDA’s Established Pharmacologic Class for it is Ergotamine Derivative.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes); the FDA directory lists 1 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $235.48 – $397.04 for 8 mL, depending on the NDC ($29.43546 to $49.63034 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 2 NDCs

70069-0880-01 · not listed as a package in the FDA directory · $49.63034 per ML · eff. 2026-09-23 filed
70069-0880-08 · Somerset Therapeutics, LLC · $29.43546 per ML · eff. 2026-09-23 filed

Other strengths, forms and brands

1 other product in the NADAC file shares the FDA nonproprietary name dihydroergotamine mesylate with DIHYDROERGOTAMINE 4 MG/ML SPRY.

Product	Pharmacies pay per unit	Medicare per unit
DIHYDROERGOTAMINE 4 MG/ML SPRY this page generic · spray, metered	$29.43546 to $49.63034 per ML filed eff. 2026-09-23	$149.45629 per ML filed Part D 2024 average
DIHYDROERGOTAMINE MESYLATE 4 MG/ML NASAL SPRAY generic · spray / spray, metered	$29.43546 to $49.63034 per ML filed eff. 2026-09-23	$149.45629 per ML filed Part D 2024 average

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

What Medicare paid

Medicare Part D paid $1,195.65 for 8 mL, at an average of $149.45629 per ML in 2024 (2024-01-01 to 2024-12-31) for “Dihydroergotamine Mesylate*” and “Dihydroergotamine Mesylate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 17,794 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

What is your cash price for 8 mL? Is it lower than what I would pay through my insurance?
Which NDC (the 11-digit number on the package) is this? Pharmacies pay $29.43546 to $49.63034 per ML for this product, depending on the NDC.
How much is in the package I am getting? This page uses 8 mL; your package may hold a different amount.
If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.

Questions

Why is the comparison with Medicare for DIHYDROERGOTAMINE 4 MG/ML SPRY labelled estimated?: Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Dihydroergotamine Mesylate* / Dihydroergotamine Mesylate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. Only NADAC NDCs whose FDA route includes NASAL point at this name (8 of the 10 the name join matched); NDCs of another route or with no known FDA route do not. 3 of the 8 NDCs that point at this name are not listed in the FDA NDC Directory as packages of their own; their route was taken from FDA's record for the same product (labeler and product code).
Why does this page start at 8 mL?: NADAC prices this product per ML. The FDA NDC Directory’s package description gives 8 mL in one package for the 1 of this product’s 2 NDCs it lists (“8 CARTON in 1 KIT (70069-880-08) / 1 VIAL in 1 CARTON (70069-880-01) / 1 mL in 1 VIAL”), so the card starts at one package: 8 ML. Change it to match your prescription.

Its pharmacologic class

Ergotamine Derivative 3 products

Related in the same class

ERGOMAR 2 MG TABLET SUBLINGUAL