ESTRADIOL VALERATE 200 MG/5 ML

What it is

ESTRADIOL VALERATE 200 MG/5 ML is how the CMS NADAC file names this product. The FDA NDC Directory lists it as estradiol valerate.

FDA gives its dosage form as “injection” and “injection, solution” and its route as intramuscular.

Its labelers, the companies named on the label, are Hikma Pharmaceuticals USA Inc., American Regent, Inc. and Xiromed, LLC.

FDA’s Established Pharmacologic Class for it is Estrogen.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $184.14 for 5 mL (5 × $36.82787 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 3 NDCs

• 00143-9291-01 · Hikma Pharmaceuticals USA Inc. · $36.82787 per ML · eff. 2026-09-23 filed
• 00517-0440-01 · American Regent, Inc. · $36.82787 per ML · eff. 2026-09-23 filed
• 70700-0275-22 · Xiromed, LLC · $36.82787 per ML · eff. 2026-09-23 filed

Other strengths, forms and brands

4 other products in the NADAC file share the FDA nonproprietary name estradiol valerate with ESTRADIOL VALERATE 200 MG/5 ML.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $36.82787 per ML filed.

Of the 6 other products in FDA’s Estrogen class priced per ML, 1 has a higher middle NADAC price and 5 a lower one. The one in the middle is ESTRADIOL VALERATE 100 MG/5 ML, at $22.64523 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $111.58 for 5 mL, at an average of $22.31668 per ML in 2024 (2024-01-01 to 2024-12-31) for “Estradiol Valerate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 14,281 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 5 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 5 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.