HYDROXYUREA 500 MG CAPSULE
For 30 capsules
Pharmacies pay
$5.51 filed
30 × $0.18364 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$8.56 filed
30 × $0.28533 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
1.6× estimated
Medicare paid 1.6× what pharmacies pay.
Part D averages every strength and form sold under “Hydroxyurea” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$11.34 estimated
$5.51 + $0.83 (15%) + $5.00 fee per fill = $11.34
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
HYDROXYUREA 500 MG CAPSULE is how the CMS NADAC file names this product. The FDA NDC Directory lists it as hydroxyurea.
FDA gives its dosage form as capsule and its route as oral.
FDA lists 6 labelers (the companies named on the label) for its NDCs, among them Teva Pharmaceuticals USA, Inc., Major Pharmaceuticals and Par Health USA, LLC.
FDA’s Established Pharmacologic Class for it is Antimetabolite.
The NADAC file of 2026-10-14 prices it under 7 NDCs (National Drug Codes); the FDA directory lists 6 of them.
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $5.51 for 30 capsules (30 × $0.18364 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.
What NADAC measures · Why 30 capsules · NADAC explanation codes
The 6 labelers
| Labeler | NDCs | Pharmacies pay per unit |
|---|---|---|
| American Health Packaging | 1 | $0.18364 per EA filed |
| Leading Pharma, LLC | 1 | $0.18364 per EA filed |
| Major Pharmaceuticals | 1 | $0.18364 per EA filed |
| Par Health USA, LLC | 1 | $0.18364 per EA filed |
| Somerset Therapeutics, LLC | 1 | $0.18364 per EA filed |
| Teva Pharmaceuticals USA, Inc. | 1 | $0.18364 per EA filed |
| Not listed as a package in the FDA directory | 1 | $0.18364 per EA filed |
All 7 NDCs, with labeler and price
- 00555-0882-02 · Teva Pharmaceuticals USA, Inc. · $0.18364 per EA · eff. 2026-09-23 filed
- 00904-6939-61 · Major Pharmaceuticals · $0.18364 per EA · eff. 2026-09-23 filed
- 49884-0724-01 · Par Health USA, LLC · $0.18364 per EA · eff. 2026-09-23 filed
- 68084-0284-01 · American Health Packaging · $0.18364 per EA · eff. 2026-09-23 filed
- 68084-0284-11 · not listed as a package in the FDA directory · $0.18364 per EA · eff. 2026-09-23 filed
- 69315-0164-01 · Leading Pharma, LLC · $0.18364 per EA · eff. 2026-09-23 filed
- 70069-0820-01 · Somerset Therapeutics, LLC · $0.18364 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
3 other products in the NADAC file share the FDA nonproprietary name hydroxyurea with HYDROXYUREA 500 MG CAPSULE.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| HYDROXYUREA 500 MG CAPSULE this page | $0.18364 per EA filed | $0.28533 per EA filed |
| SIKLOS 1,000 MG TABLET | $61.99589 per EA filed | $33.5651 per EA filed |
| SIKLOS 100 MG TABLET | $6.23183 per EA filed | $33.5651 per EA filed |
| XROMI 100 MG/ML SOLUTION | $4.96667 per ML filed | We don’t know yet |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
What Medicare paid
Medicare Part D paid $8.56 for 30 capsules, at an average of $0.28533 per EA in 2024 (2024-01-01 to 2024-12-31) for “Hydroxyurea”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 521,514 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 30 capsules? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for HYDROXYUREA 500 MG CAPSULE labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Hydroxyurea / Hydroxyurea: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name.