KLAYESTA 100,000 UNIT/GM POWD
FDA nonproprietary name: nystatin topical powder
For 1 g
Pharmacies pay
$0.26 – $0.42 filed
1 × $0.25738 to $0.42143 per GM (the 3 NDCs differ)
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$0.47 filed
1 × $0.46566 per GM, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
1.1× – 1.8× estimated
Medicare paid between 1.1× and 1.8× what pharmacies pay, depending on the NDC.
Part D averages every strength and form sold under “Klayesta” / “Nystatin” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$5.30 – $5.48 estimated
NADAC for the pack + 15% + $5.00 fee per fill
This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
KLAYESTA 100,000 UNIT/GM POWD is how the CMS NADAC file names this product. The FDA NDC Directory lists it as nystatin topical powder, under the trade name “KLAYESTA”.
FDA gives its dosage form as powder and its route as topical.
The labeler, the company named on the label, is Epic Pharma, LLC.
FDA’s Established Pharmacologic Class for it is Polyene Antifungal.
The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $0.26 – $0.42 for 1 g, depending on the NDC ($0.25738 to $0.42143 per GM), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
What NADAC measures · NADAC explanation codes
All 3 NDCs
- 42806-0186-15 · Epic Pharma, LLC · $0.42143 per GM · eff. 2026-09-23 filed
- 42806-0186-30 · Epic Pharma, LLC · $0.31335 per GM · eff. 2026-09-23 filed
- 42806-0186-60 · Epic Pharma, LLC · $0.25738 per GM · eff. 2026-09-23 filed
Compared with its class
The middle of its 3 NDCs’ NADAC prices is $0.31335 per GM filed.
Of the 8 other products in FDA’s Polyene Antifungal class priced per GM, 0 have a higher middle NADAC price and 5 a lower one; 3 have the same. The one in the middle is NYSTATIN-TRIAMCINOLONE OINTM, at $0.26518 per GM filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $0.47 for 1 g, at an average of $0.46566 per GM in 2024 (2024-01-01 to 2024-12-31) for “Klayesta” and “Nystatin”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 129,701 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 g? Is it lower than what I would pay through my insurance?
- Which NDC (the 11-digit number on the package) is this? Pharmacies pay $0.25738 to $0.42143 per GM for this product, depending on the NDC.
- How much is in the package I am getting? This page uses 1 g; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for KLAYESTA 100,000 UNIT/GM POWD labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Klayesta / Nystatin: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's GM. Joined on brand name.
- Why does this page start at 1 g?
- The FDA package descriptions of this product’s NDCs give different amounts (15 g, 30 g, 60 g). So the card starts at 1 GM; change it to match your prescription.