LEUCOVORIN CALCIUM 25 MG TAB
For 30 tablets
Pharmacies pay
$48.14 filed
30 × $1.60475 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$69.52 filed
30 × $2.31748 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
1.4× estimated
Medicare paid 1.4× what pharmacies pay.
Part D averages every strength and form sold under “Leucovorin Calcium*” / “Leucovorin Calcium” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$60.36 estimated
$48.14 + $7.22 (15%) + $5.00 fee per fill = $60.36
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
LEUCOVORIN CALCIUM 25 MG TAB is how the CMS NADAC file names this product. The FDA NDC Directory lists it as leucovorin calcium.
FDA gives its dosage form as tablet and its route as oral.
FDA lists 7 labelers (the companies named on the label) for its NDCs, among them Hikma Pharmaceuticals USA Inc., Teva Pharmaceuticals USA, Inc. and Major Pharmaceuticals.
FDA’s Established Pharmacologic Class for it is Folate Analog.
The NADAC file of 2026-10-14 prices it under 8 NDCs (National Drug Codes); the FDA directory lists 7 of them.
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $48.14 for 30 tablets (30 × $1.60475 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.
What NADAC measures · Why 30 tablets · NADAC explanation codes
The 7 labelers
| Labeler | NDCs | Pharmacies pay per unit |
|---|---|---|
| American Health Packaging | 1 | $1.60475 per EA filed |
| Epic Pharma LLC | 1 | $1.60475 per EA filed |
| Hikma Pharmaceuticals USA Inc. | 1 | $1.60475 per EA filed |
| Ingenus Pharmaceuticals, LLC | 1 | $1.60475 per EA filed |
| Leading Pharma, LLC | 1 | $1.60475 per EA filed |
| Major Pharmaceuticals | 1 | $1.60475 per EA filed |
| Teva Pharmaceuticals USA, Inc. | 1 | $1.60475 per EA filed |
| Not listed as a package in the FDA directory | 1 | $1.60475 per EA filed |
All 8 NDCs, with labeler and price
- 00054-4499-11 · Hikma Pharmaceuticals USA Inc. · $1.60475 per EA · eff. 2026-09-23 filed
- 00555-0485-27 · Teva Pharmaceuticals USA, Inc. · $1.60475 per EA · eff. 2026-09-23 filed
- 00904-7584-10 · Major Pharmaceuticals · $1.60475 per EA · eff. 2026-09-23 filed
- 42806-0359-25 · Epic Pharma LLC · $1.60475 per EA · eff. 2026-09-23 filed
- 50742-0184-25 · Ingenus Pharmaceuticals, LLC · $1.60475 per EA · eff. 2026-09-23 filed
- 60687-0227-11 · not listed as a package in the FDA directory · $1.60475 per EA · eff. 2026-09-23 filed
- 60687-0227-94 · American Health Packaging · $1.60475 per EA · eff. 2026-09-23 filed
- 69315-0187-25 · Leading Pharma, LLC · $1.60475 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
3 other products in the NADAC file share the FDA nonproprietary name leucovorin calcium with LEUCOVORIN CALCIUM 25 MG TAB.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| LEUCOVORIN CALCIUM 5 MG TAB | $0.33003 per EA filed | $2.31748 per EA filed |
| LEUCOVORIN CALCIUM 10 MG TAB | $2.07783 per EA filed | $2.31748 per EA filed |
| LEUCOVORIN CALCIUM 15 MG TAB | $1.58667 per EA filed | $2.31748 per EA filed |
| LEUCOVORIN CALCIUM 25 MG TAB this page | $1.60475 per EA filed | $2.31748 per EA filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
The middle of its 8 NDCs’ NADAC prices is $1.60475 per EA filed.
Of the 9 other products in FDA’s Folate Analog class priced per EA, 7 have a higher middle NADAC price and 2 a lower one. The one in the middle is VITAFOL ULTRA SOFTGEL, at $4.52255 per EA filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $69.52 for 30 tablets, at an average of $2.31748 per EA in 2024 (2024-01-01 to 2024-12-31) for “Leucovorin Calcium*” and “Leucovorin Calcium”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 104,039 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for LEUCOVORIN CALCIUM 25 MG TAB labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Leucovorin Calcium* / Leucovorin Calcium: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. All 31 NADAC NDCs the name join matched to it have an FDA route including ORAL. 1 of the 31 NDCs that point at this name is not listed in the FDA NDC Directory as a package of its own; its route was taken from FDA's record for the same product (labeler and product code).
Related pages
Its pharmacologic class
Related in the same class
- VITAFOL ULTRA SOFTGEL
- PRENATE MINI SOFTGEL
- VITAFOL FE PLUS SOFTGEL
- ENBRACE HR SOFTGEL
- PRENATE DHA SOFTGEL