LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM

What it is

LIDOCAINE-PRILOCAINE 2.5%-2.5% CREAM is how the CMS NADAC file names this product. The FDA NDC Directory lists it as lidocaine and prilocaine, under the trade name “LIDOCAINE AND PRILOCAINE LIDOCAINE AND PRILOCAINE”.

FDA gives its dosage form as cream and its route as topical.

FDA lists 5 labelers (the companies named on the label) for its NDCs, among them E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, Padagis US LLC and Encube Ethicals, Inc.

FDA lists it under 2 Established Pharmacologic Classes: Amide Local Anesthetic and Antiarrhythmic.

The NADAC file of 2026-10-14 prices it under 8 NDCs (National Drug Codes); the FDA directory lists 7 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $0.23 – $1.34 for 1 g, depending on the NDC ($0.2317 to $1.33527 per GM), by the CMS NADAC file of 2026-10-14; those prices took effect between 2026-07-22 and 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 4, carried forward from the previous file; 5, calculated based on package size.

The NADAC of 3 of these 8 NDCs was carried forward from an earlier file (NADAC explanation code 2 or 4), not newly surveyed: those prices took effect on 2026-07-22. The file is new; the price is not.

What NADAC measures · NADAC explanation codes · Carried-forward prices

The 5 labelers

When these prices took effect

• 2026-09-23 · 5 NDCs · $0.2317 per GM filed
• 2026-07-22 · 3 NDCs, all carried forward from an earlier file · $1.33527 per GM filed

Compared with its class

The middle of its 8 NDCs’ NADAC prices is $0.2317 per GM filed.

Of the 9 other products in FDA’s Amide Local Anesthetic class priced per GM, 5 have a higher middle NADAC price and 4 a lower one. The one in the middle is LIDOCAINE 3% CREAM, at $0.36487 per GM filed (eff. 2026-09-23).

Of the 9 other products in FDA’s Antiarrhythmic class priced per GM, 5 have a higher middle NADAC price and 4 a lower one. The one in the middle is LIDOCAINE 3% CREAM, at $0.36487 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $0.43 for 1 g, at an average of $0.4281 per GM in 2024 (2024-01-01 to 2024-12-31) for “Lidocaine-Prilocaine” and “Lidocaine/Prilocaine”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 421,178 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 g? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $0.2317 to $1.33527 per GM for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 1 g; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.