LYLLANA 0.1 MG PATCH

What it is

LYLLANA 0.1 MG PATCH is how the CMS NADAC file names this product. The FDA NDC Directory lists it as estradiol, under the trade name “LYLLANA”.

FDA gives its dosage form as patch, extended release and its route as transdermal.

The labeler, the company named on the label, is Amneal Pharmaceuticals LLC.

FDA’s Established Pharmacologic Class for it is Estrogen.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes); the FDA directory lists 1 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $8.57 for 1 patch (1 × $8.56811 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.

What NADAC measures · NADAC explanation codes

All 2 NDCs

• 65162-0228-04 · not listed as a package in the FDA directory · $8.56811 per EA · eff. 2026-09-23 filed
• 65162-0228-08 · Amneal Pharmaceuticals LLC · $8.56811 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

59 other products in the NADAC file share the FDA nonproprietary name estradiol with LYLLANA 0.1 MG PATCH. The 23 below share a strength or dosage form with it first; search OpenBill for the rest.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 2 NDCs’ NADAC prices is $8.56811 per EA filed.

Of the 104 other products in FDA’s Estrogen class priced per EA, 44 have a higher middle NADAC price and 58 a lower one; 2 have the same. The one in the middle is LYLLANA 0.075 MG PATCH, at $8.11285 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $6.83 for 1 patch, at an average of $6.83197 per EA in 2024 (2024-01-01 to 2024-12-31) for “Lyllana” and “Estradiol”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 24,542 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 patch? Is it lower than what I would pay through my insurance?
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.