MIGRAINE 250-250-65 MG CPLT

What it is

MIGRAINE 250-250-65 MG CPLT is how the CMS NADAC file names this product. The FDA NDC Directory lists it as acetaminophen, aspirin, caffeine, under the trade names “Leader Migraine Relief” and “good neighbor pharmacy migraine relief”.

FDA gives its dosage form as tablet, film coated and its route as oral.

Its labelers, the companies named on the label, are Amerisource Bergen and Cardinal Health 110, LLC. dba Leader.

FDA lists it under 4 Established Pharmacologic Classes: Central Nervous System Stimulant, Methylxanthine, Nonsteroidal Anti-inflammatory Drug and Platelet Aggregation Inhibitor.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and marks it as sold over the counter.

What pharmacies pay

Pharmacies pay $1.94 for 30 tablets (30 × $0.06482 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.

What NADAC measures · Why 30 tablets · NADAC explanation codes

All 3 NDCs

• 24385-0365-71 · Amerisource Bergen · $0.06482 per EA · eff. 2026-09-23 filed
• 70000-0247-01 · Cardinal Health 110, LLC. dba Leader · $0.06482 per EA · eff. 2026-09-23 filed
• 70000-0247-02 · Cardinal Health 110, LLC. dba Leader · $0.06482 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

8 other products in the NADAC file share the FDA nonproprietary name acetaminophen, aspirin, caffeine with MIGRAINE 250-250-65 MG CPLT.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $0.06482 per EA filed.

Of the 203 other products in FDA’s Central Nervous System Stimulant class priced per EA, 192 have a higher middle NADAC price and 2 a lower one; 9 have the same. The one in the middle is FOCALIN XR 5 MG CAPSULE, at $4.70352 per EA filed (eff. 2026-09-23).

Of the 32 other products in FDA’s Methylxanthine class priced per EA, 21 have a higher middle NADAC price and 2 a lower one; 9 have the same. The one in the middle is BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET, at $0.12231 per EA filed (eff. 2026-09-23).

Of the 154 other products in FDA’s Nonsteroidal Anti-inflammatory Drug class priced per EA, 101 have a higher middle NADAC price and 44 a lower one; 9 have the same. The one in the middle is ACETAMINOPHEN-IBUPROFEN 250-125 MG TABLET, at $0.10711 per EA filed (eff. 2026-10-07).

Of the 35 other products in FDA’s Platelet Aggregation Inhibitor class priced per EA, 7 have a higher middle NADAC price and 19 a lower one; 9 have the same. The one in the middle is SM ASPIRIN 81 MG CHEWABLE TAB, at $0.02571 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23, 2026-10-07 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

We don’t know yet; the card above says why.

Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
• It is sold over the counter, so shelf prices vary from store to store: what does it cost per unit here?
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.