NAPROXEN-ESOMEPRAZ DR 500-20 MG

What it is

NAPROXEN-ESOMEPRAZ DR 500-20 MG is how the CMS NADAC file names this product. The FDA NDC Directory lists it as naproxen and esomeprazole magnesium.

FDA gives its dosage form as tablet, delayed release and its route as oral.

Its labelers, the companies named on the label, are Ajanta Pharma USA Inc., ScieGen Pharmaceuticals, Inc and Dr. Reddy's Laboratories Limited.

FDA lists it under 2 Established Pharmacologic Classes: Nonsteroidal Anti-inflammatory Drug and Proton Pump Inhibitor.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $58.75 for 30 tablets (30 × $1.95826 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.

What NADAC measures · Why 30 tablets · NADAC explanation codes

All 3 NDCs

• 27241-0203-60 · Ajanta Pharma USA Inc. · $1.95826 per EA · eff. 2026-09-23 filed
• 50228-0438-60 · ScieGen Pharmaceuticals, Inc · $1.95826 per EA · eff. 2026-09-23 filed
• 55111-0701-60 · Dr. Reddy's Laboratories Limited · $1.95826 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

1 other product in the NADAC file shares the FDA nonproprietary name naproxen and esomeprazole magnesium with NAPROXEN-ESOMEPRAZ DR 500-20 MG.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-07-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $1.95826 per EA filed.

Of the 154 other products in FDA’s Nonsteroidal Anti-inflammatory Drug class priced per EA, 24 have a higher middle NADAC price and 130 a lower one. The one in the middle is INDOMETHACIN 25 MG CAPSULE, at $0.09341 per EA filed (eff. 2026-09-23).

Of the 61 other products in FDA’s Proton Pump Inhibitor class priced per EA, 31 have a higher middle NADAC price and 30 a lower one. The one in the middle is LANSOPRAZOLE DR 30 MG ODT, at $2.25583 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $436.45 for 30 tablets, at an average of $14.54837 per EA in 2024 (2024-01-01 to 2024-12-31) for “Naproxen-Esomeprazole Mag” and “Naproxen/Esomeprazole Mag”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 15,135 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.