PROGRAF 0.5 MG CAPSULE
FDA nonproprietary name: tacrolimus
For 30 capsules
Pharmacies pay
$109.77 filed
30 × $3.65915 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$177.91 filed
30 × $5.93047 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
1.6× estimated
Medicare paid 1.6× what pharmacies pay.
Part D averages every strength and form sold under “Prograf*” / “Tacrolimus” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$131.24 estimated
$109.77 + $16.47 (15%) + $5.00 fee per fill = $131.24
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
PROGRAF 0.5 MG CAPSULE is how the CMS NADAC file names this product. The FDA NDC Directory lists it as tacrolimus, under the trade name “Prograf”.
FDA gives its dosage form as capsule, gelatin coated and its route as oral.
The labeler, the company named on the label, is Astellas Pharma US, Inc.
FDA’s Established Pharmacologic Class for it is Calcineurin Inhibitor Immunosuppressant.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00469-0607-73.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $109.77 for 30 capsules (30 × $3.65915 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.
NADAC also lists, on the row of one brand NDC, what pharmacies pay for the generic equivalent, a different product: $0.12274 per EA filed.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What NADAC measures · Why 30 capsules · NADAC explanation codes
The NDC
- 00469-0607-73 · Astellas Pharma US, Inc. · $3.65915 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
8 other products in the NADAC file share the FDA nonproprietary name tacrolimus with PROGRAF 0.5 MG CAPSULE.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| PROGRAF 0.2 MG GRANULE PACKET | $5.01513 per EA filed | $5.93047 per EA filed |
| PROGRAF 0.5 MG CAPSULE this page | $3.65915 per EA filed | $5.93047 per EA filed |
| PROGRAF 1 MG CAPSULE | $7.32732 per EA filed | $5.93047 per EA filed |
| PROGRAF 1 MG GRANULE PACKET | $7.4446 per EA filed | $5.93047 per EA filed |
| TACROLIMUS 0.03% OINTMENT | $0.88777 to $0.99827 per GM filed | We don’t know yet |
| TACROLIMUS 0.1% OINTMENT | $0.94262 to $0.98159 per GM filed | We don’t know yet |
| TACROLIMUS 0.5 MG CAPSULE (IMMEDIATE RELEASE) | $0.12274 per EA filed | $0.081 per EA derived |
| TACROLIMUS 1 MG CAPSULE (IMMEDIATE RELEASE) | $0.1535 per EA filed | $0.162 per EA derived |
| TACROLIMUS 5 MG CAPSULE (IMMEDIATE RELEASE) | $0.68805 per EA filed | $0.81 per EA derived |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
Its NADAC price is $3.65915 per EA filed.
Of the 19 other products in FDA’s Calcineurin Inhibitor Immunosuppressant class priced per EA, 8 have a higher middle NADAC price and 11 a lower one. The one in the middle is ASTAGRAF XL 0.5 MG CAPSULE, at $2.88173 per EA filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $177.91 for 30 capsules, at an average of $5.93047 per EA in 2024 (2024-01-01 to 2024-12-31) for “Prograf*” and “Tacrolimus”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 4,634 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 30 capsules? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for PROGRAF 0.5 MG CAPSULE labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Prograf* / Tacrolimus: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on brand name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. All 4 NADAC NDCs the name join matched to it have an FDA route including ORAL.