PROTRIPTYLINE HCL 10 MG TABLET

What it is

PROTRIPTYLINE HCL 10 MG TABLET is how the CMS NADAC file names this product. The FDA NDC Directory lists it as protriptyline hydrochloride.

FDA gives its dosage form as tablet, film coated and its route as oral.

Its labelers, the companies named on the label, are Sigmapharm Laboratories, LLC and Epic Pharma, LLC.

FDA’s Established Pharmacologic Class for it is Tricyclic Antidepressant.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes); the FDA directory lists 2 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $81.33 for 30 tablets (30 × $2.71097 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.

What NADAC measures · Why 30 tablets · NADAC explanation codes

All 3 NDCs

• 00054-0211-25 · not listed as a package in the FDA directory · $2.71097 per EA · eff. 2026-09-23 filed
• 42794-0007-02 · Sigmapharm Laboratories, LLC · $2.71097 per EA · eff. 2026-09-23 filed
• 42806-0097-30 · Epic Pharma, LLC · $2.71097 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

1 other product in the NADAC file shares the FDA nonproprietary name protriptyline hydrochloride with PROTRIPTYLINE HCL 10 MG TABLET.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $2.71097 per EA filed.

Of the 34 other products in FDA’s Tricyclic Antidepressant class priced per EA, 2 have a higher middle NADAC price and 32 a lower one. The one in the middle is DOXEPIN 75 MG CAPSULE, at $0.19659 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $81.23 for 30 tablets, at an average of $2.70768 per EA in 2024 (2024-01-01 to 2024-12-31) for “Protriptyline HCl”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 5,889 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.