PULMOZYME 1 MG/ML AMPUL
FDA nonproprietary name: dornase alfa
For 75 mL
Pharmacies pay
$3,986.77 filed
75 × $53.15693 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$3,755.02 filed
75 × $50.06688 per ML, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
0.94× estimated
Medicare paid 6% less than pharmacies pay.
Part D averages every strength and form sold under “Pulmozyme” / “Dornase Alfa” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$4,589.79 estimated
$3,986.77 + $598.02 (15%) + $5.00 fee per fill = $4,589.79
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
PULMOZYME 1 MG/ML AMPUL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as dornase alfa, under the trade name “Pulmozyme”.
FDA gives its dosage form as solution and its route as respiratory (inhalation).
The labeler, the company named on the label, is Genentech, Inc.
FDA’s Established Pharmacologic Class for it is Recombinant Human Deoxyribonuclease 1.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 50242-0100-40.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $3,986.77 for 75 mL (75 × $53.15693 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
What NADAC measures · NADAC explanation codes
The NDC
- 50242-0100-40 · Genentech, Inc. · $53.15693 per ML · eff. 2026-09-23 filed
What Medicare paid
Medicare Part D paid $3,755.02 for 75 mL, at an average of $50.06688 per ML in 2024 (2024-01-01 to 2024-12-31) for “Pulmozyme” and “Dornase Alfa”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 443 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 75 mL? Is it lower than what I would pay through my insurance?
- How much is in the package I am getting? This page uses 75 mL; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for PULMOZYME 1 MG/ML AMPUL labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Pulmozyme / Dornase Alfa: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
- Why does this page start at 75 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 75 mL in one package for this product’s NDC (“5 POUCH in 1 CARTON (50242-100-40) / 6 AMPULE in 1 POUCH (50242-100-39) / 2.5 mL in 1 AMPULE”), so the card starts at one package: 75 ML. Change it to match your prescription.