Why is the comparison with Medicare for VYZULTA 0.024% OPHTH SOLUTION labelled estimated?

Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Vyzulta / Latanoprostene Bunod: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.

Why does this page start at 1 mL?

The FDA package descriptions of this product’s NDCs give different amounts (2.5 mL, 5 mL). So the card starts at 1 ML; change it to match your prescription.

VYZULTA 0.024% OPHTH SOLUTION

FDA nonproprietary name: latanoprostene bunod

For 1 mL

Pharmacies pay

$102.25 – $102.29 filed

1 × $102.25131 to $102.28986 per ML (the 2 NDCs differ)

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D paid

$98.84 filed

1 × $98.83817 per ML, Part D average

Medicare's price is not your price.

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

The spread

0.97× estimated

Medicare paid about what pharmacies pay.

Part D averages every strength and form sold under “Vyzulta” / “Latanoprostene Bunod” into one figure, so it is not specific to this NDC.

OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)

Cost-plus estimate

$122.59 – $122.63 estimated

NADAC for the pack + 15% + $5.00 fee per fill

This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out

OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)

Open the interactive card Change the quantity, type what you were charged, and see every record in full.

What it is

VYZULTA 0.024% OPHTH SOLUTION is how the CMS NADAC file names this product. The FDA NDC Directory lists it as latanoprostene bunod, under the trade name “Vyzulta”.

FDA gives its dosage form as solution/ drops and its route as ophthalmic.

The labeler, the company named on the label, is Bausch & Lomb Incorporated.

FDA lists no Established Pharmacologic Class for it.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $102.25 – $102.29 for 1 mL, depending on the NDC ($102.25131 to $102.28986 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 2 NDCs

24208-0504-02 · Bausch & Lomb Incorporated · $102.28986 per ML · eff. 2026-09-23 filed
24208-0504-05 · Bausch & Lomb Incorporated · $102.25131 per ML · eff. 2026-09-23 filed

What Medicare paid

Medicare Part D paid $98.84 for 1 mL, at an average of $98.83817 per ML in 2024 (2024-01-01 to 2024-12-31) for “Vyzulta” and “Latanoprostene Bunod”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 292,207 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
Which NDC (the 11-digit number on the package) is this? Pharmacies pay $102.25131 to $102.28986 per ML for this product, depending on the NDC.
How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.

Questions

Why is the comparison with Medicare for VYZULTA 0.024% OPHTH SOLUTION labelled estimated?: Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Vyzulta / Latanoprostene Bunod: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
Why does this page start at 1 mL?: The FDA package descriptions of this product’s NDCs give different amounts (2.5 mL, 5 mL). So the card starts at 1 ML; change it to match your prescription.