XYOSTED 50 MG/0.5 ML AUTO-INJ
FDA nonproprietary name: testosterone enanthate
For 2 mL
Pharmacies pay
$632.42 filed
2 × $316.2082 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$603.47 filed
2 × $301.73645 per ML, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
0.95× estimated
Medicare paid about what pharmacies pay.
Part D averages every strength and form sold under “Xyosted” / “Testosterone Enanthate” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$732.28 estimated
$632.42 + $94.86 (15%) + $5.00 fee per fill = $732.28
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
XYOSTED 50 MG/0.5 ML AUTO-INJ is how the CMS NADAC file names this product. The FDA NDC Directory lists it as testosterone enanthate, under the trade name “XYOSTED”.
FDA gives its dosage form as injection and its route as subcutaneous.
The labeler, the company named on the label, is Antares Pharma, Inc.
FDA’s Established Pharmacologic Class for it is Androgen.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 54436-0250-04.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $632.42 for 2 mL (2 × $316.2082 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
What NADAC measures · NADAC explanation codes
The NDC
- 54436-0250-04 · Antares Pharma, Inc. · $316.2082 per ML · eff. 2026-09-23 filed
Other strengths, forms and brands
3 other products in the NADAC file share the FDA nonproprietary name testosterone enanthate with XYOSTED 50 MG/0.5 ML AUTO-INJ.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| TESTOSTERON ENAN 1,000 MG/5 ML | $14.4763 per ML filed | $12.85998 per ML filed |
| XYOSTED 50 MG/0.5 ML AUTO-INJ this page | $316.2082 per ML filed | $301.73645 per ML filed |
| XYOSTED 75 MG/0.5 ML AUTO-INJ | $316.38038 per ML filed | $301.73645 per ML filed |
| XYOSTED 100 MG/0.5 ML AUTO-INJ | $316.50058 per ML filed | $301.73645 per ML filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
Its NADAC price is $316.2082 per ML filed.
Of the 8 other products in FDA’s Androgen class priced per ML, 2 have a higher middle NADAC price and 6 a lower one. The one in the middle is DEPO-TESTOSTERONE 1,000 MG/10 ML, at $6.91704 per ML filed (eff. 2025-12-17).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2025-12-17, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $603.47 for 2 mL, at an average of $301.73645 per ML in 2024 (2024-01-01 to 2024-12-31) for “Xyosted” and “Testosterone Enanthate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 36,669 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 2 mL? Is it lower than what I would pay through my insurance?
- How much is in the package I am getting? This page uses 2 mL; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for XYOSTED 50 MG/0.5 ML AUTO-INJ labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Xyosted / Testosterone Enanthate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
- Why does this page start at 2 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 2 mL in one package for this product’s NDC (“4 SYRINGE in 1 CARTON (54436-250-04) / .5 mL in 1 SYRINGE (54436-250-02)”), so the card starts at one package: 2 ML. Change it to match your prescription.