BREZTRI AEROSPHERE 160-9-4.8 MCG

What it is

BREZTRI AEROSPHERE 160-9-4.8 MCG is how the CMS NADAC file names this product. The FDA NDC Directory lists it as budesonide, glycopyrrolate, and formoterol fumarate, under the trade name “BREZTRI”.

FDA gives its dosage form as aerosol, metered and its route as respiratory (inhalation).

The labeler, the company named on the label, is AstraZeneca Pharmaceuticals LP.

FDA lists it under 4 Established Pharmacologic Classes: Anticholinergic, beta2-Adrenergic Agonist, Cholinergic Muscarinic Antagonist and Corticosteroid.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $61.30 – $61.52 for 1 g, depending on the NDC ($61.30387 to $61.52481 per GM), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 2 NDCs

• 00310-4616-12 · AstraZeneca Pharmaceuticals LP · $61.30387 per GM · eff. 2026-09-23 filed
• 00310-4616-39 · AstraZeneca Pharmaceuticals LP · $61.52481 per GM · eff. 2026-09-23 filed

Compared with its class

The middle of its 2 NDCs’ NADAC prices is $61.30387 per GM filed.

Of the 7 other products in FDA’s Anticholinergic class priced per GM, 4 have a higher middle NADAC price and 3 a lower one. The one in the middle is STIOLTO RESPIMAT INHALER (60), at $115.80015 per GM filed (eff. 2026-09-23).

Of the 24 other products in FDA’s beta2-Adrenergic Agonist class priced per GM, 3 have a higher middle NADAC price and 21 a lower one. The one in the middle is FLUTICASONE-SALMETEROL 115-21, at $20.70767 per GM filed (eff. 2026-09-23).

Of the 122 other products in FDA’s Corticosteroid class priced per GM, 2 have a higher middle NADAC price and 120 a lower one. The one in the middle is CALCIPOTRIENE-BETAMETHASONE DP 0.005%-0.064% OINTMENT, at $1.43306 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $58.03 for 1 g, at an average of $58.02868 per GM in 2024 (2024-01-01 to 2024-12-31) for “Breztri Aerosphere” and “Budesonide/Glycopyr/Formoterol”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 1,431,108 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 g? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $61.30387 to $61.52481 per GM for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 1 g; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.