BRIMONIDINE-TIMOLOL 0.2%-0.5%

What it is

BRIMONIDINE-TIMOLOL 0.2%-0.5% is how the CMS NADAC file names this product. The FDA NDC Directory lists it as brimonidine tartrate and timolol maleate, under the trade names “Brimonidine Tartrate/Timolol Maleate” and “Brimonidine Tartrate/Timolol Maleate Ophthalmic Solution”.

FDA gives its dosage form as “solution/ drops” and “solution” and its route as ophthalmic.

FDA lists 10 labelers (the companies named on the label) for its NDCs, among them Sandoz Inc, Upsher-Smith Laboratories, LLC and Apotex Corp.

FDA lists it under 2 Established Pharmacologic Classes: alpha-Adrenergic Agonist and beta-Adrenergic Blocker.

The NADAC file of 2026-10-14 prices it under 30 NDCs (National Drug Codes); the FDA directory lists 27 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $1.97 – $2.72 for 1 mL, depending on the NDC ($1.97168 to $2.71747 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

The 10 labelers

Compared with its class

The middle of its 30 NDCs’ NADAC prices is $2.15126 per ML filed.

Of the 14 other products in FDA’s alpha-Adrenergic Agonist class priced per ML, 8 have a higher middle NADAC price and 6 a lower one. The one in the middle is ADRENALIN 1 MG/ML VIAL, at $7.79554 per ML filed (eff. 2025-10-28).

Of the 19 other products in FDA’s beta-Adrenergic Blocker class priced per ML, 12 have a higher middle NADAC price and 7 a lower one. The one in the middle is TIMOLOL 0.5% GEL-SOLUTION, at $8.30197 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2025-10-28, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $16.98 for 1 mL, at an average of $16.98404 per ML in 2024 (2024-01-01 to 2024-12-31) for “Brimonidine Tartrate-Timolol” and “Brimonidine Tartrate/Timolol”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 530,348 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $1.97168 to $2.71747 per ML for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.