COMBIGAN 0.2%-0.5% EYE DROPS

What it is

COMBIGAN 0.2%-0.5% EYE DROPS is how the CMS NADAC file names this product. The FDA NDC Directory lists it as brimonidine tartrate, timolol maleate, under the trade name “COMBIGAN”.

FDA gives its dosage form as solution/ drops and its route as ophthalmic.

The labeler, the company named on the label, is Allergan, Inc.

FDA lists it under 2 Established Pharmacologic Classes: alpha-Adrenergic Agonist and beta-Adrenergic Blocker.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $39.09 – $39.16 for 1 mL, depending on the NDC ($39.09128 to $39.15623 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

NADAC also lists, on the row of its brand NDCs, what pharmacies pay for the generic equivalent, a different product: $1.97168 to $2.71747 per ML filed.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

What NADAC measures · NADAC explanation codes

All 3 NDCs

• 00023-9211-05 · Allergan, Inc. · $39.15623 per ML · eff. 2026-09-23 filed
• 00023-9211-10 · Allergan, Inc. · $39.09588 per ML · eff. 2026-09-23 filed
• 00023-9211-15 · Allergan, Inc. · $39.09128 per ML · eff. 2026-09-23 filed

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $39.09588 per ML filed.

Of the 14 other products in FDA’s alpha-Adrenergic Agonist class priced per ML, 1 has a higher middle NADAC price and 13 a lower one. The one in the middle is BRIMONIDINE-TIMOLOL 0.2%-0.5%, at $2.15126 per ML filed (eff. 2026-09-23).

Of the 19 other products in FDA’s beta-Adrenergic Blocker class priced per ML, 2 have a higher middle NADAC price and 17 a lower one. The one in the middle is TIMOLOL 0.25% GEL-SOLUTION, at $6.37609 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $38.75 for 1 mL, at an average of $38.74669 per ML in 2024 (2024-01-01 to 2024-12-31) for “Combigan” and “Brimonidine Tartrate/Timolol”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 465,280 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $39.09128 to $39.15623 per ML for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.