BUPIVACAINE 0.25% VIAL

What it is

BUPIVACAINE 0.25% VIAL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as bupivacaine hydrochloride, under the trade name “Bupivacaine HCl”.

FDA gives its dosage form as injection, solution and its route as “infiltration; perineural” and “perineural”.

Its labelers, the companies named on the label, are Somerset Therapeutics, LLC, Xellia Pharmaceuticals USA LLC and Meitheal Pharmaceuticals Inc.

FDA’s Established Pharmacologic Class for it is Amide Local Anesthetic.

The NADAC file of 2026-10-14 prices it under 5 NDCs (National Drug Codes); the FDA directory lists 3 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $2.40 for 50 mL (50 × $0.04792 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-05-20. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 4, carried forward from the previous file; 5, calculated based on package size.

The NADAC of all 5 NDCs was carried forward from an earlier file (NADAC explanation code 2 or 4), not newly surveyed: those prices took effect on 2026-05-20. The file is new; the price is not.

What NADAC measures · NADAC explanation codes · Carried-forward prices

All 5 NDCs

• 00143-9328-01 · not listed as a package in the FDA directory · $0.04792 per ML · eff. 2026-05-20 filed carried forward
• 00409-1160-18 · not listed as a package in the FDA directory · $0.04792 per ML · eff. 2026-05-20 filed carried forward
• 70069-0752-01 · Somerset Therapeutics, LLC · $0.04792 per ML · eff. 2026-05-20 filed carried forward
• 70594-0116-01 · Xellia Pharmaceuticals USA LLC · $0.04792 per ML · eff. 2026-05-20 filed carried forward
• 71288-0723-52 · Meitheal Pharmaceuticals Inc · $0.04792 per ML · eff. 2026-05-20 filed carried forward

Other strengths, forms and brands

1 other product in the NADAC file shares the FDA nonproprietary name bupivacaine hydrochloride with BUPIVACAINE 0.25% VIAL.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-22, 2026-05-20 · as of 2026-10-14 · retrieved 2026-10-17

OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)

Compared with its class

The middle of its 5 NDCs’ NADAC prices is $0.04792 per ML filed.

Of the 21 other products in FDA’s Amide Local Anesthetic class priced per ML, 21 have a higher middle NADAC price and 0 a lower one. The one in the middle is LIDOCAINE 1%-EPI 1:100,000, at $0.13908 per ML filed (eff. 2026-07-22).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-05-20, 2026-07-22 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part B’s payment limit for HCPCS J0665, for 2026-10-01 to 2026-12-31, comes to $2.50 for 50 mL, or $0.05 per ML once converted to NADAC’s unit for this product.

Medicare Part B pays for a drug like this only in specific settings, such as a drug given in a clinic or doctor’s office or used with certain medical equipment; most prescriptions filled at a pharmacy are paid by Part D.

The patient’s share under Part B (coinsurance, 20% of the limit, before deductibles and other coverage) is $0.002 per 0.5 MG.

2 of the product’s 5 NDCs have this Medicare figure; the other 3 do not, and the interactive card says why for each.

Medicare's price is not your price.

What the Part B payment limit is · Converting it to the NADAC unit · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 50 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 50 mL; your package may hold a different amount.
• If you have Medicare Part B: is this drug covered for me in this setting, and what is my share?
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.