BUPROPION HCL XL 450 MG TABLET

What it is

BUPROPION HCL XL 450 MG TABLET is how the CMS NADAC file names this product. The FDA NDC Directory lists it as “bupropion hcl er” and “bupropion hydrochloride”, as its NDCs’ listings variously write the nonproprietary name, under the trade name “BUPROPION HCl ER (XL)”.

FDA gives its dosage form as “tablet, film coated, extended release” and “tablet, extended release” and its route as oral.

Its labelers, the companies named on the label, are Upsher-Smith Laboratories, LLC and Lifestar Pharma LLC.

FDA’s Established Pharmacologic Class for it is Aminoketone.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $239.87 for 30 tablets (30 × $7.99556 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · Why 30 tablets · NADAC explanation codes

All 2 NDCs

• 24979-0248-06 · Upsher-Smith Laboratories, LLC · $7.99556 per EA · eff. 2026-09-23 filed
• 70756-0830-30 · Lifestar Pharma LLC · $7.99556 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

10 other products in the NADAC file share an FDA nonproprietary name with BUPROPION HCL XL 450 MG TABLET.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23, 2026-09-30 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 2 NDCs’ NADAC prices is $7.99556 per EA filed.

Of the 11 other products in FDA’s Aminoketone class priced per EA, 2 have a higher middle NADAC price and 9 a lower one. The one in the middle is BUPROPION HCL SR 200 MG TABLET, at $0.10362 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $12.11 for 30 tablets, at an average of $0.40383 per EA in 2024 (2024-01-01 to 2024-12-31) for “Bupropion XL” and “Bupropion HCl”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 6,831,216 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

1 of the product’s 2 NDCs have this Medicare figure; the other 1 do not, and the interactive card says why for each.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.