COMPRO 25 MG SUPPOSITORY

What it is

COMPRO 25 MG SUPPOSITORY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as prochlorperazine, under the trade name “Compro”.

FDA gives its dosage form as suppository and its route as rectal.

The labeler, the company named on the label, is Padagis US LLC.

FDA’s Established Pharmacologic Class for it is Phenothiazine.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00574-7226-12.

NADAC classes it in its brand rate-setting class B-ANDA, and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $6.74 for 1 suppository (1 × $6.74227 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

NADAC also lists, on the row of one brand NDC, what pharmacies pay for the generic equivalent, a different product: $4.86511 per EA filed.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

What NADAC measures · NADAC explanation codes

The NDC

• 00574-7226-12 · Padagis US LLC · $6.74227 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

1 other product in the NADAC file shares the FDA nonproprietary name prochlorperazine with COMPRO 25 MG SUPPOSITORY.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

Its NADAC price is $6.74227 per EA filed.

Of the 32 other products in FDA’s Phenothiazine class priced per EA, 1 has a higher middle NADAC price and 31 a lower one. The one in the middle is CHLORPROMAZINE 50 MG TABLET, at $0.41446 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $6.58 for 1 suppository, at an average of $6.58366 per EA in 2024 (2024-01-01 to 2024-12-31) for “Compro” and “Prochlorperazine”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 10,507 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 suppository? Is it lower than what I would pay through my insurance?
• Is a generic version available, and would it suit me? NADAC lists a generic with the same ingredient, strength and dosage form by FDA: PROCHLORPERAZINE 25 MG SUPP. Ask your pharmacist or prescriber; do not switch on your own.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.