CYCLOSPORINE 0.05% EYE EMULSION
For 1 unit (EA)
Pharmacies pay
$0.91 – $1.18 filed
1 × $0.90945 to $1.18033 per EA (the 16 NDCs differ)
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$4.33 filed
1 × $4.32927 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
3.7× – 4.8× estimated
Medicare paid between 3.7× and 4.8× what pharmacies pay, depending on the NDC.
Part D averages every strength and form sold under “Cyclosporine*” / “Cyclosporine” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$6.05 – $6.36 estimated
NADAC for the pack + 15% + $5.00 fee per fill
This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
CYCLOSPORINE 0.05% EYE EMULSION is how the CMS NADAC file names this product. The FDA NDC Directory lists it as cyclosporine.
FDA gives its dosage form as emulsion and its route as ophthalmic.
FDA lists 8 labelers (the companies named on the label) for its NDCs, among them Mylan Pharmaceuticals Inc., Teva Pharmaceuticals, Inc. and KVK-TECH, INC.
FDA’s Established Pharmacologic Class for it is Calcineurin Inhibitor Immunosuppressant.
The NADAC file of 2026-10-14 prices it under 16 NDCs (National Drug Codes).
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $0.91 – $1.18 for 1 unit (EA), depending on the NDC ($0.90945 to $1.18033 per EA), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.
What NADAC measures · NADAC explanation codes
The 8 labelers
| Labeler | NDCs | Pharmacies pay per unit |
|---|---|---|
| Apotex Corp | 2 | $0.90945 to $1.18033 per EA filed |
| Devatis Inc. | 2 | $0.90945 to $1.18033 per EA filed |
| KVK-TECH, INC. | 2 | $0.90945 to $1.18033 per EA filed |
| Lupin Pharmaceuticals, Inc. | 2 | $0.90945 to $1.18033 per EA filed |
| Mylan Pharmaceuticals Inc. | 2 | $0.90945 to $1.18033 per EA filed |
| Saptalis Pharmaceuticals, LLC | 2 | $0.90945 to $1.18033 per EA filed |
| Teva Pharmaceuticals, Inc. | 2 | $0.90945 to $1.18033 per EA filed |
| Upsher-Smith Laboratories, LLC | 2 | $0.90945 to $1.18033 per EA filed |
All 16 NDCs, with labeler and price
- 00378-8760-58 · Mylan Pharmaceuticals Inc. · $1.18033 per EA · eff. 2026-09-23 filed
- 00378-8760-91 · Mylan Pharmaceuticals Inc. · $0.90945 per EA · eff. 2026-09-23 filed
- 00480-4076-30 · Teva Pharmaceuticals, Inc. · $1.18033 per EA · eff. 2026-09-23 filed
- 00480-4076-60 · Teva Pharmaceuticals, Inc. · $0.90945 per EA · eff. 2026-09-23 filed
- 10702-0808-03 · KVK-TECH, INC. · $1.18033 per EA · eff. 2026-09-23 filed
- 10702-0808-06 · KVK-TECH, INC. · $0.90945 per EA · eff. 2026-09-23 filed
- 24979-0126-18 · Upsher-Smith Laboratories, LLC · $0.90945 per EA · eff. 2026-09-23 filed
- 24979-0126-19 · Upsher-Smith Laboratories, LLC · $1.18033 per EA · eff. 2026-09-23 filed
- 60505-6202-01 · Apotex Corp · $1.18033 per EA · eff. 2026-09-23 filed
- 60505-6202-02 · Apotex Corp · $0.90945 per EA · eff. 2026-09-23 filed
- 68180-0214-30 · Lupin Pharmaceuticals, Inc. · $1.18033 per EA · eff. 2026-09-23 filed
- 68180-0214-60 · Lupin Pharmaceuticals, Inc. · $0.90945 per EA · eff. 2026-09-23 filed
- 71656-0012-30 · Saptalis Pharmaceuticals, LLC · $1.18033 per EA · eff. 2026-09-23 filed
- 71656-0012-60 · Saptalis Pharmaceuticals, LLC · $0.90945 per EA · eff. 2026-09-23 filed
- 73043-0005-01 · Devatis Inc. · $1.18033 per EA · eff. 2026-09-23 filed
- 73043-0005-02 · Devatis Inc. · $0.90945 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
12 other products in the NADAC file share the FDA nonproprietary name cyclosporine with CYCLOSPORINE 0.05% EYE EMULSION.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| CEQUA 0.09% SOLUTION | $10.38279 per EA filed | $9.33517 per EA filed |
| CYCLOSPORINE 0.05% EYE EMULSION this page | $0.90945 to $1.18033 per EA filed | $4.32927 per EA filed |
| CYCLOSPORINE 25 MG CAPSULE | $2.5957 per EA filed | $0.576 per EA derived |
| CYCLOSPORINE 100 MG CAPSULE | $7.50676 per EA filed | $1.455 per EA derived |
| CYCLOSPORINE MODIFIED 25 MG | $0.31377 per EA filed | $0.576 per EA derived |
| CYCLOSPORINE MODIFIED 50 MG | $0.76459 per EA filed | $0.7275 to $1.152 per EA derived |
| CYCLOSPORINE MODIFIED 100 MG | $1.23348 per EA filed | $1.455 per EA derived |
| CYCLOSPORINE MODIFIED 100 MG/ML | $2.03685 per ML filed | $1.455 per ML derived |
| GENGRAF 25 MG CAPSULE | $1.86549 per EA filed | $1.14257 per EA filed |
| NEORAL 25 MG GELATIN CAPSULE | $2.94566 per EA filed | $3.90784 per EA filed |
| NEORAL 100 MG GELATIN CAPSULE | $11.7731 per EA filed | $3.90784 per EA filed |
| RESTASIS 0.05% EYE EMULSION | $10.31247 to $10.31333 per EA filed | $10.19841 per EA filed |
| RESTASIS MULTIDOSE 0.05% EYE | $112.32159 per ML filed | $111.93625 per ML filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-01-02, 2026-07-08, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
The middle of its 16 NDCs’ NADAC prices is $0.90945 per EA filed.
Of the 19 other products in FDA’s Calcineurin Inhibitor Immunosuppressant class priced per EA, 14 have a higher middle NADAC price and 5 a lower one. The one in the middle is NEORAL 25 MG GELATIN CAPSULE, at $2.94566 per EA filed (eff. 2026-07-08).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-07-08, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $4.33 for 1 unit (EA), at an average of $4.32927 per EA in 2024 (2024-01-01 to 2024-12-31) for “Cyclosporine*” and “Cyclosporine”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 744,577 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 unit (EA)? Is it lower than what I would pay through my insurance?
- Which NDC (the 11-digit number on the package) is this? Pharmacies pay $0.90945 to $1.18033 per EA for this product, depending on the NDC.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for CYCLOSPORINE 0.05% EYE EMULSION labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Cyclosporine* / Cyclosporine: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. Only NADAC NDCs whose FDA route includes OPHTHALMIC point at this name (16 of the 22 the name join matched); NDCs of another route or with no known FDA route do not.
- Why does this page start at 1 unit (EA)?
- NADAC prices this product per EA, and the FDA NDC Directory lists its 16 NDCs as dosage form “EMULSION” with route “OPHTHALMIC”. Only a tablet, capsule, lozenge or troche with route “ORAL”, or a tablet or film with route “SUBLINGUAL” or “BUCCAL”, starts at 30, and none of these is one. NADAC’s EA for it may be a whole package (such as a kit, pen, syringe, vial or inhaler) or one dose inside it, and the files do not say which. So the card starts at 1 unit (EA) rather than guess how many make up a fill; change it to match your prescription.