ESTRADIOL 0.025 MG PATCH(1/WK)

What it is

ESTRADIOL 0.025 MG PATCH(1/WK) is how the CMS NADAC file names this product. The FDA NDC Directory lists it as estradiol, under the trade name “Estradiol Transdermal System”.

FDA gives its dosage form as patch and its route as transdermal.

Its labelers, the companies named on the label, are Mylan Pharmaceuticals Inc. and Sandoz Inc.

FDA’s Established Pharmacologic Class for it is Estrogen.

The NADAC file of 2026-10-14 prices it under 4 NDCs (National Drug Codes); the FDA directory lists 2 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $11.75 for 1 patch (1 × $11.75493 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

All 4 NDCs

• 00378-3349-16 · not listed as a package in the FDA directory · $11.75493 per EA · eff. 2026-09-23 filed
• 00378-3349-99 · Mylan Pharmaceuticals Inc. · $11.75493 per EA · eff. 2026-09-23 filed
• 00781-7119-54 · Sandoz Inc · $11.75493 per EA · eff. 2026-09-23 filed
• 00781-7119-58 · not listed as a package in the FDA directory · $11.75493 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

59 other products in the NADAC file share the FDA nonproprietary name estradiol with ESTRADIOL 0.025 MG PATCH(1/WK). The 23 below share a strength or dosage form with it first; search OpenBill for the rest.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 4 NDCs’ NADAC prices is $11.75493 per EA filed.

Of the 104 other products in FDA’s Estrogen class priced per EA, 33 have a higher middle NADAC price and 71 a lower one. The one in the middle is LYLLANA 0.075 MG PATCH, at $8.11285 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

We don’t know yet; the card above says why.

Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 patch? Is it lower than what I would pay through my insurance?
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.