DIVIGEL 0.5 MG GEL PACKET
FDA nonproprietary name: estradiol
For 1 unit (EA)
Pharmacies pay
$5.39 filed
1 × $5.39183 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare
We don’t know yet
No Medicare reference price. Part D: OpenBill did not match this NDC to a usable Medicare Part D spending row. Either Part D has none for it, or the rows that share its name could not safely be tied to it (for example, they mix units, routes or release forms, or the drug is sold over the counter, which Part D does not cover). Part B: This NDC is not in the current quarter’s Medicare Part B NDC-HCPCS crosswalk, so it has no Part B payment limit.
The spread
We don’t know yet
There is no Medicare figure to compare with, so there is no spread.
Cost-plus estimate
$11.20 estimated
$5.39 + $0.81 (15%) + $5.00 fee per fill = $11.20
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
DIVIGEL 0.5 MG GEL PACKET is how the CMS NADAC file names this product. The FDA NDC Directory lists it as estradiol, under the trade name “DIVIGEL”.
FDA gives its dosage form as gel and its route as topical.
The labeler, the company named on the label, is Vertical Pharmaceuticals, LLC.
FDA’s Established Pharmacologic Class for it is Estrogen.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 68025-0066-30.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $5.39 for 1 unit (EA) (1 × $5.39183 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
NADAC also lists, on the row of one brand NDC, what pharmacies pay for the generic equivalent, a different product: $0.95477 per EA filed.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What NADAC measures · NADAC explanation codes
The NDC
- 68025-0066-30 · Vertical Pharmaceuticals, LLC · $5.39183 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
59 other products in the NADAC file share the FDA nonproprietary name estradiol with DIVIGEL 0.5 MG GEL PACKET. The 23 below share a strength or dosage form with it first; search OpenBill for the rest.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| CLIMARA 0.025 MG/DAY PATCH | $18.22764 per EA filed | $13.21368 per EA filed |
| CLIMARA 0.0375 MG/DAY PATCH | $18.29817 per EA filed | $13.21368 per EA filed |
| CLIMARA 0.05 MG/DAY PATCH | $18.25678 per EA filed | $13.21368 per EA filed |
| CLIMARA 0.06 MG/DAY PATCH | $18.14596 per EA filed | $13.21368 per EA filed |
| CLIMARA 0.075 MG/DAY PATCH | $18.25087 per EA filed | $13.21368 per EA filed |
| CLIMARA 0.1 MG/DAY PATCH | $18.27935 per EA filed | $13.21368 per EA filed |
| DIVIGEL 0.25 MG GEL PACKET | $5.388 per EA filed | We don’t know yet |
| DIVIGEL 0.5 MG GEL PACKET this page | $5.39183 per EA filed | We don’t know yet |
| DIVIGEL 0.75 MG GEL PACKET | $5.40611 per EA filed | We don’t know yet |
| DIVIGEL 1 MG GEL PACKET | $5.38098 per GM filed | We don’t know yet |
| DIVIGEL 1.25 MG GEL PACKET | $4.29397 per GM filed | We don’t know yet |
| DOTTI 0.025 MG PATCH | $7.7577 per EA filed | $7.04054 per EA filed |
| DOTTI 0.0375 MG PATCH | $8.26227 per EA filed | $7.04054 per EA filed |
| DOTTI 0.05 MG PATCH | $8.50358 per EA filed | $7.04054 per EA filed |
| DOTTI 0.075 MG PATCH | $8.11285 per EA filed | $7.04054 per EA filed |
| DOTTI 0.1 MG PATCH | $8.56811 per EA filed | $7.04054 per EA filed |
| ELESTRIN 0.06% GEL | $3.60934 per GM filed | $4.6929 per GM filed |
| ESTRACE 0.01% CREAM | $7.76131 per GM filed | $6.00834 per GM filed |
| ESTRADIOL 0.06% 1.25G GEL PUMP | $3.38721 per GM filed | We don’t know yet |
| ESTRADIOL 0.1% (0.25 MG) GEL PK | $0.75703 per EA filed | We don’t know yet |
| ESTRADIOL 0.1% (0.5 MG) GEL PKT | $0.95477 per EA filed | We don’t know yet |
| ESTRADIOL 0.1% (0.75 MG) GEL PK | $0.59192 per EA filed | We don’t know yet |
| ESTRADIOL 0.1% (1 MG) GEL PKT | $0.96726 per GM filed | We don’t know yet |
| ESTRADIOL 0.1% (1.25 MG) GEL PK | $0.73351 per GM filed | We don’t know yet |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
Its NADAC price is $5.39183 per EA filed.
Of the 104 other products in FDA’s Estrogen class priced per EA, 74 have a higher middle NADAC price and 30 a lower one. The one in the middle is DOTTI 0.0375 MG PATCH, at $8.26227 per EA filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
We don’t know yet; the card above says why.
Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 unit (EA)? Is it lower than what I would pay through my insurance?
- Is a generic version available, and would it suit me? NADAC lists a generic with the same ingredient, strength and dosage form by FDA: ESTRADIOL 0.1% (0.5 MG) GEL PKT. Ask your pharmacist or prescriber; do not switch on your own.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why does this page start at 1 unit (EA)?
- NADAC prices this product per EA, and the FDA NDC Directory lists its NDC as dosage form “GEL” with route “TOPICAL”. Only a tablet, capsule, lozenge or troche with route “ORAL”, or a tablet or film with route “SUBLINGUAL” or “BUCCAL”, starts at 30, and this is not one. NADAC’s EA for it may be a whole package (such as a kit, pen, syringe, vial or inhaler) or one dose inside it, and the files do not say which. So the card starts at 1 unit (EA) rather than guess how many make up a fill; change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- PREMARIN 0.3 MG TABLET
- PREMPRO 0.3 MG-1.5 MG TABLET
- ABIGALE 1 MG-0.5 MG TABLET
- ESTRADIOL VALERATE 100 MG/5 ML
- NORTREL 1-35 21 TABLET