HUMALOG 100 UNIT/ML CARTRIDGE
FDA nonproprietary name: insulin lispro
For 15 mL
Pharmacies pay
$146.78 filed
15 × $9.78555 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$92.77 filed
15 × $6.18454 per ML, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
0.63× estimated
Medicare paid 37% less than pharmacies pay.
Part D averages every strength and form sold under “Humalog” / “Insulin Lispro” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$173.80 estimated
$146.78 + $22.02 (15%) + $5.00 fee per fill = $173.80
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
HUMALOG 100 UNIT/ML CARTRIDGE is how the CMS NADAC file names this product. The FDA NDC Directory lists it as insulin lispro, under the trade name “Humalog”.
FDA gives its dosage form as injection, solution and its route as intravenous; subcutaneous.
The labeler, the company named on the label, is Eli Lilly and Company.
FDA’s Established Pharmacologic Class for it is Insulin Analog.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00002-7516-59.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $146.78 for 15 mL (15 × $9.78555 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
What NADAC measures · NADAC explanation codes
The NDC
- 00002-7516-59 · Eli Lilly and Company · $9.78555 per ML · eff. 2026-09-23 filed
Other strengths, forms and brands
14 other products in the NADAC file share the FDA nonproprietary name insulin lispro with HUMALOG 100 UNIT/ML CARTRIDGE.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| ADMELOG 100 UNIT/ML VIAL | $9.39379 to $12.56125 per ML filed | $9.7762 per ML filed |
| ADMELOG SOLOSTAR 100 UNIT/ML | $12.10918 per ML filed | $6.232 per ML derived |
| HUMALOG 100 UNIT/ML CARTRIDGE this page | $9.78555 per ML filed | $6.18454 per ML filed |
| HUMALOG 100 UNIT/ML KWIKPEN | $10.16762 per ML filed | $9.91201 per ML filed |
| HUMALOG 100 UNIT/ML VIAL | $6.35737 per ML filed | $6.18454 per ML filed |
| HUMALOG 200 UNIT/ML KWIKPEN | $20.31012 per ML filed | $65.66237 per ML filed |
| HUMALOG JR 100 UNIT/ML KWIKPEN | $10.15829 per ML filed | $9.9833 per ML filed |
| HUMALOG MIX 50-50 KWIKPEN | $10.14137 per ML filed | We don’t know yet |
| HUMALOG MIX 75-25 KWIKPEN | $10.1667 per ML filed | We don’t know yet |
| HUMALOG MIX 75-25 VIAL | $8.15257 per ML filed | We don’t know yet |
| HUMALOG TEMPO PEN 100 UNIT/ML | $10.12721 per ML filed | $6.232 per ML derived |
| INSULIN LISPRO 100 UNIT/ML KWIKPEN | $10.19333 per ML filed | $10.20103 per ML filed |
| INSULIN LISPRO 100 UNIT/ML VL | $2.40265 per ML filed | $2.49228 per ML filed |
| INSULIN LISPRO JR 100 UNIT/ML KWIKPEN | $10.19937 per ML filed | $10.08062 per ML filed |
| INSULIN LISPRO MIX 75-25 KWKPN | $10.20743 per ML filed | We don’t know yet |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-06-17, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
Its NADAC price is $9.78555 per ML filed.
Of the 56 other products in FDA’s Insulin Analog class priced per ML, 27 have a higher middle NADAC price and 29 a lower one. The one in the middle is TRESIBA FLEXTOUCH 100 UNIT/ML, at $9.03577 per ML filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $92.77 for 15 mL, at an average of $6.18454 per ML in 2024 (2024-01-01 to 2024-12-31) for “Humalog” and “Insulin Lispro”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 511,120 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 15 mL? Is it lower than what I would pay through my insurance?
- How much is in the package I am getting? This page uses 15 mL; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for HUMALOG 100 UNIT/ML CARTRIDGE labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Humalog / Insulin Lispro: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
- Why does this page start at 15 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 15 mL in one package for this product’s NDC (“5 CARTRIDGE in 1 CARTON (0002-7516-59) / 3 mL in 1 CARTRIDGE (0002-7516-01)”), so the card starts at one package: 15 ML. Change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- LANTUS SOLOSTAR 100 UNIT/ML
- NOVOLOG 100 UNIT/ML FLEXPEN
- TRESIBA FLEXTOUCH 100 UNIT/ML
- FIASP 100 UNIT/ML FLEXTOUCH
- SOLIQUA 100 UNIT-33 MCG/ML PEN