ISTALOL 0.5% EYE DROPS
FDA nonproprietary name: timolol maleate
For 1 mL
Pharmacies pay
$79.76 – $80.01 filed
1 × $79.76333 to $80.01457 per ML (the 2 NDCs differ)
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-06-17, 2026-07-22 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$78.54 filed
1 × $78.53935 per ML, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
0.98× estimated
Medicare paid about what pharmacies pay.
Part D averages every strength and form sold under “Istalol” / “Timolol Maleate” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-06-17, 2026-07-22 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$96.72 – $97.01 estimated
NADAC for the pack + 15% + $5.00 fee per fill
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-06-17, 2026-07-22 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
ISTALOL 0.5% EYE DROPS is how the CMS NADAC file names this product. The FDA NDC Directory lists it as timolol maleate, under the trade name “Istalol”.
FDA gives its dosage form as solution/ drops and its route as ophthalmic.
The labeler, the company named on the label, is Bausch & Lomb Incorporated.
FDA’s Established Pharmacologic Class for it is beta-Adrenergic Blocker.
The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $79.76 – $80.01 for 1 mL, depending on the NDC ($79.76333 to $80.01457 per ML), by the CMS NADAC file of 2026-10-14; those prices took effect between 2026-06-17 and 2026-07-22. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 4, carried forward from the previous file; 5, calculated based on package size.
The NADAC of all 2 NDCs was carried forward from an earlier file (NADAC explanation code 2 or 4), not newly surveyed: those prices took effect on 2026-06-17, 2026-07-22. The file is new; the price is not.
NADAC also lists, on the row of its brand NDCs, what pharmacies pay for the generic equivalent, a different product: $21.80573 to $22.28973 per ML filed.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What NADAC measures · NADAC explanation codes · Carried-forward prices
All 2 NDCs
- 24208-0004-01 · Bausch & Lomb Incorporated · $79.76333 per ML · eff. 2026-06-17 filed carried forward
- 24208-0004-03 · Bausch & Lomb Incorporated · $80.01457 per ML · eff. 2026-07-22 filed carried forward
Other strengths, forms and brands
8 other products in the NADAC file share the FDA nonproprietary name timolol maleate with ISTALOL 0.5% EYE DROPS.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| ISTALOL 0.5% EYE DROPS this page | $79.76333 to $80.01457 per ML filed | $78.53935 per ML filed |
| TIMOLOL 0.25% GEL-SOLUTION | $6.37609 per ML filed | $2.00991 per ML filed |
| TIMOLOL 0.5% EYE DROP | $21.80573 to $22.28973 per ML filed | We don’t know yet |
| TIMOLOL 0.5% GEL-SOLUTION | $8.30197 per ML filed | $2.00991 per ML filed |
| TIMOLOL 0.5% GFS GEL-SOLUTION | $8.30197 per ML filed | $2.00991 per ML filed |
| TIMOLOL MALEATE 0.25% EYE DROP | $0.60023 to $0.64657 per ML; $6.10159 per EA filed | We don’t know yet |
| TIMOLOL MALEATE 0.5% EYE DROP | $1.25546 per EA filed | We don’t know yet |
| TIMOLOL MALEATE 0.5% EYE DROPS | $0.71967 to $1.046 per ML filed | We don’t know yet |
| TIMOPTIC 0.5% OCUDOSE DROP | $10.32362 per EA filed | We don’t know yet |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-06-17, 2026-07-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
The middle of its 2 NDCs’ NADAC prices is $79.76333 per ML filed.
Of the 19 other products in FDA’s beta-Adrenergic Blocker class priced per ML, 0 have a higher middle NADAC price and 19 a lower one. The one in the middle is TIMOLOL 0.25% GEL-SOLUTION, at $6.37609 per ML filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-06-17, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $78.54 for 1 mL, at an average of $78.53935 per ML in 2024 (2024-01-01 to 2024-12-31) for “Istalol” and “Timolol Maleate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 1,279 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
- Which NDC (the 11-digit number on the package) is this? Pharmacies pay $79.76333 to $80.01457 per ML for this product, depending on the NDC.
- Is a generic version available, and would it suit me? NADAC lists a generic with the same ingredient, strength and dosage form by FDA: TIMOLOL 0.5% EYE DROP. Ask your pharmacist or prescriber; do not switch on your own.
- How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for ISTALOL 0.5% EYE DROPS labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Istalol / Timolol Maleate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
- Why does this page start at 1 mL?
- The FDA package descriptions of this product’s NDCs give different amounts (2.5 mL, 5 mL). So the card starts at 1 ML; change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- METOPROLOL SUCC ER 100 MG TAB
- METOPROLOL TARTRATE 100 MG TAB
- CARVEDILOL 12.5 MG TABLET
- ATENOLOL 100 MG TABLET
- PROPRANOLOL 10 MG TABLET