LUBIPROSTONE 24 MCG CAPSULE
For 30 capsules
Pharmacies pay
$19.52 filed
30 × $0.6507 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$50.03 filed
30 × $1.66781 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
2.6× estimated
Medicare paid 2.6× what pharmacies pay.
Part D averages every strength and form sold under “Lubiprostone” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$27.45 estimated
$19.52 + $2.93 (15%) + $5.00 fee per fill = $27.45
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
LUBIPROSTONE 24 MCG CAPSULE is how the CMS NADAC file names this product. The FDA NDC Directory lists it as lubiprostone.
FDA gives its dosage form as “capsule, gelatin coated” and “capsule” and its route as oral.
FDA lists 9 labelers (the companies named on the label) for its NDCs, among them Par Health USA, LLC, Teva Pharmaceuticals, Inc. and Camber Pharmaceuticals, Inc.
FDA’s Established Pharmacologic Class for it is Chloride Channel Activator.
The NADAC file of 2026-10-14 prices it under 11 NDCs (National Drug Codes); the FDA directory lists 9 of them.
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $19.52 for 30 capsules (30 × $0.6507 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.
What NADAC measures · Why 30 capsules · NADAC explanation codes
The 9 labelers
| Labeler | NDCs | Pharmacies pay per unit |
|---|---|---|
| American Health Packaging | 1 | $0.6507 per EA filed |
| Camber Pharmaceuticals, Inc. | 1 | $0.6507 per EA filed |
| Dr. Reddy's Laboratories Inc. | 1 | $0.6507 per EA filed |
| Natco Pharma USA LLC | 1 | $0.6507 per EA filed |
| Northstar Rx LLC | 1 | $0.6507 per EA filed |
| Par Health USA, LLC | 1 | $0.6507 per EA filed |
| Sun Pharmaceutical Industries, Inc. | 1 | $0.6507 per EA filed |
| Teva Pharmaceuticals, Inc. | 1 | $0.6507 per EA filed |
| Zydus Pharmaceuticals USA Inc. | 1 | $0.6507 per EA filed |
| Not listed as a package in the FDA directory | 2 | $0.6507 per EA filed |
All 11 NDCs, with labeler and price
- 00254-3029-02 · Par Health USA, LLC · $0.6507 per EA · eff. 2026-09-23 filed
- 00480-4138-06 · Teva Pharmaceuticals, Inc. · $0.6507 per EA · eff. 2026-09-23 filed
- 31722-0404-60 · Camber Pharmaceuticals, Inc. · $0.6507 per EA · eff. 2026-09-23 filed
- 43598-0168-60 · Dr. Reddy's Laboratories Inc. · $0.6507 per EA · eff. 2026-09-23 filed
- 60687-0827-32 · American Health Packaging · $0.6507 per EA · eff. 2026-09-23 filed
- 60687-0827-33 · not listed as a package in the FDA directory · $0.6507 per EA · eff. 2026-09-23 filed
- 63304-0352-60 · Sun Pharmaceutical Industries, Inc. · $0.6507 per EA · eff. 2026-09-23 filed
- 69339-0163-17 · Natco Pharma USA LLC · $0.6507 per EA · eff. 2026-09-23 filed
- 69339-0163-98 · not listed as a package in the FDA directory · $0.6507 per EA · eff. 2026-09-23 filed
- 70710-1642-06 · Zydus Pharmaceuticals USA Inc. · $0.6507 per EA · eff. 2026-09-23 filed
- 72603-0289-01 · Northstar Rx LLC · $0.6507 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
3 other products in the NADAC file share the FDA nonproprietary name lubiprostone with LUBIPROSTONE 24 MCG CAPSULE.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| AMITIZA 8 MCG CAPSULE | $6.46774 per EA filed | $5.65006 per EA filed |
| AMITIZA 24 MCG CAPSULE | $6.44889 per EA filed | $5.65006 per EA filed |
| LUBIPROSTONE 8 MCG CAPSULE | $0.56517 per EA filed | $1.66781 per EA filed |
| LUBIPROSTONE 24 MCG CAPSULE this page | $0.6507 per EA filed | $1.66781 per EA filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
Compared with its class
The middle of its 11 NDCs’ NADAC prices is $0.6507 per EA filed.
Of the 3 other products in FDA’s Chloride Channel Activator class priced per EA, 2 have a higher middle NADAC price and 1 a lower one. The one in the middle is AMITIZA 24 MCG CAPSULE, at $6.44889 per EA filed (eff. 2026-04-22).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $50.03 for 30 capsules, at an average of $1.66781 per EA in 2024 (2024-01-01 to 2024-12-31) for “Lubiprostone”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 440,018 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 30 capsules? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for LUBIPROSTONE 24 MCG CAPSULE labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Lubiprostone / Lubiprostone: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name.