METHOTREXATE 250 MG/10 ML VIAL

What it is

METHOTREXATE 250 MG/10 ML VIAL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as “methotrexate sodium” and “methotrexate”, as its NDCs’ listings variously write the nonproprietary name.

FDA gives its dosage form as “injection, solution” and “injection” and its route as “intra-arterial; intramuscular; intrathecal; intravenous” and “intra-arterial; intramuscular; intravenous”.

Its labelers, the companies named on the label, are Teva Parenteral Medicines, Inc., Accord Healthcare, Inc. and Fresenius Kabi USA, LLC.

FDA’s Established Pharmacologic Class for it is Folate Analog Metabolic Inhibitor.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $7.02 – $31.83 for 10 mL, depending on the NDC ($0.702 to $3.1832 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 3 NDCs

• 00703-3675-01 · Teva Parenteral Medicines, Inc. · $0.702 per ML · eff. 2026-09-23 filed
• 16729-0277-03 · Accord Healthcare, Inc. · $0.702 per ML · eff. 2026-09-23 filed
• 63323-0123-10 · Fresenius Kabi USA, LLC · $3.1832 per ML · eff. 2026-09-23 filed

Other strengths, forms and brands

13 other products in the NADAC file share an FDA nonproprietary name with METHOTREXATE 250 MG/10 ML VIAL.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. between 2026-01-01 and 2026-09-23 (4 dates) · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $0.702 per ML filed.

Of the 9 other products in FDA’s Folate Analog Metabolic Inhibitor class priced per ML, 9 have a higher middle NADAC price and 0 a lower one. The one in the middle is RASUVO 17.5 MG/0.35 ML AUTOINJ, at $409.92919 per ML filed (eff. 2026-04-01).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-01, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part B’s payment limit for HCPCS J9260, for 2026-10-01 to 2026-12-31, comes to $14.55 for 10 mL, or $1.4545 per ML once converted to NADAC’s unit for this product.

Medicare Part B pays for a drug like this only in specific settings, such as a drug given in a clinic or doctor’s office or used with certain medical equipment; most prescriptions filled at a pharmacy are paid by Part D.

The patient’s share under Part B (coinsurance, 20% of the limit, before deductibles and other coverage) is $0.5818 per 50 MG.

Medicare's price is not your price.

What the Part B payment limit is · Converting it to the NADAC unit · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 10 mL? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $0.702 to $3.1832 per ML for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 10 mL; your package may hold a different amount.
• If you have Medicare Part B: is this drug covered for me in this setting, and what is my share?
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.