METHOTREXATE 50 MG/2 ML VIAL

What it is

METHOTREXATE 50 MG/2 ML VIAL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as methotrexate.

FDA gives its dosage form as “solution”, “injection, solution” and “injection” and its route as “intra-arterial; intramuscular; intrathecal; intravenous”, “intramuscular; intrathecal; intravenous; subcutaneous” and “intramuscular; intravenous; subcutaneous”.

FDA lists 4 labelers (the companies named on the label) for its NDCs, among them Hikma Pharmaceuticals USA Inc., Teva Parenteral Medicines, Inc. and Accord Healthcare, Inc.

FDA’s Established Pharmacologic Class for it is Folate Analog Metabolic Inhibitor.

The NADAC file of 2026-10-14 prices it under 7 NDCs (National Drug Codes); the FDA directory lists 6 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $1.24 – $3.18 for 1 mL, depending on the NDC ($1.23696 to $3.1832 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

The 4 labelers

Other strengths, forms and brands

13 other products in the NADAC file share the FDA nonproprietary name methotrexate with METHOTREXATE 50 MG/2 ML VIAL.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. between 2026-01-01 and 2026-09-23 (4 dates) · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)

Compared with its class

The middle of its 7 NDCs’ NADAC prices is $1.80329 per ML filed.

Of the 9 other products in FDA’s Folate Analog Metabolic Inhibitor class priced per ML, 8 have a higher middle NADAC price and 1 a lower one. The one in the middle is RASUVO 17.5 MG/0.35 ML AUTOINJ, at $409.92919 per ML filed (eff. 2026-04-01).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-01, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part B’s payment limit for HCPCS J9260, for 2026-10-01 to 2026-12-31, comes to $1.45 for 1 mL, or $1.4545 per ML once converted to NADAC’s unit for this product.

Medicare Part B pays for a drug like this only in specific settings, such as a drug given in a clinic or doctor’s office or used with certain medical equipment; most prescriptions filled at a pharmacy are paid by Part D.

The patient’s share under Part B (coinsurance, 20% of the limit, before deductibles and other coverage) is $0.5818 per 50 MG.

6 of the product’s 7 NDCs have this Medicare figure; the other 1 do not, and the interactive card says why for each.

Medicare's price is not your price.

What the Part B payment limit is · Converting it to the NADAC unit · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $1.23696 to $3.1832 per ML for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
• If you have Medicare Part B: is this drug covered for me in this setting, and what is my share?
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.