Why is the comparison with Medicare for OLOPATADINE 665 MCG NASAL SPRY labelled estimated?

Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Olopatadine HCl* / Olopatadine HCl: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's GM. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. All 3 NADAC NDCs the name join matched to it have an FDA route including NASAL.

Why does this page start at 1 g?

The FDA package description of NDC 45802-0104-01 (“1 BOTTLE in 1 CARTON (45802-104-01) / 240 SPRAY in 1 BOTTLE”) does not give one amount in g, NADAC’s unit for this product. So the card starts at 1 GM; change it to match your prescription.

OLOPATADINE 665 MCG NASAL SPRY

For 1 g

Pharmacies pay

$0.85 filed

1 × $0.8495 per GM

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D paid

$5.77 filed

1 × $5.76735 per GM, Part D average

Medicare's price is not your price.

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

The spread

6.8× estimated

Medicare paid 6.8× what pharmacies pay.

Part D averages every strength and form sold under “Olopatadine HCl*” / “Olopatadine HCl” into one figure, so it is not specific to this NDC.

OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)

Cost-plus estimate

$5.98 estimated

$0.85 + $0.13 (15%) + $5.00 fee per fill = $5.98

This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out

OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)

Open the interactive card Change the quantity, type what you were charged, and see every record in full.

What it is

OLOPATADINE 665 MCG NASAL SPRY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as olopatadine hydrochloride.

FDA gives its dosage form as “spray” and “spray, metered” and its route as nasal.

Its labelers, the companies named on the label, are Padagis Israel Pharmaceuticals Ltd, Apotex Corp. and Amneal Pharmaceuticals LLC.

FDA lists it under 3 Established Pharmacologic Classes: Histamine-1 Receptor Antagonist, Histamine-1 Receptor Inhibitor and Mast Cell Stabilizer.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $0.85 for 1 g (1 × $0.8495 per GM, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 3 NDCs

45802-0104-01 · Padagis Israel Pharmaceuticals Ltd · $0.8495 per GM · eff. 2026-09-23 filed
60505-0845-05 · Apotex Corp. · $0.8495 per GM · eff. 2026-09-23 filed
65162-0890-23 · Amneal Pharmaceuticals LLC · $0.8495 per GM · eff. 2026-09-23 filed

Other strengths, forms and brands

8 other products in the NADAC file share the FDA nonproprietary name olopatadine hydrochloride with OLOPATADINE 665 MCG NASAL SPRY.

Product	Pharmacies pay per unit	Medicare per unit
ADVANCED EYE RELIEF 0.2% DROPS generic · solution	$1.98349 per ML filed eff. 2026-09-23	We don’t know yet
GNP OLOPATADINE 0.1% EYE DROPS generic · solution	$1.27369 per ML filed eff. 2026-09-23	We don’t know yet
GNP OLOPATADINE 0.2% EYE DROP generic · solution	$2.96362 per ML filed eff. 2026-09-23	We don’t know yet
OLOPATADINE 665 MCG NASAL SPRY this page generic · spray / spray, metered	$0.8495 per GM filed eff. 2026-09-23	$5.76735 per GM filed Part D 2024 average
OLOPATADINE HCL 0.1% EYE DROP generic · solution / solution/ drops	$1.27369 per ML filed eff. 2026-09-23	We don’t know yet
OLOPATADINE HCL 0.2% EYE DROP generic · solution/ drops / solution	$1.98349 to $2.96362 per ML filed eff. 2026-09-23	We don’t know yet
PATADAY ONCE DAILY 0.2% DROPS brand · solution	$5.89285 per ML filed eff. 2026-08-19	We don’t know yet
PATADAY ONCE DAILY 0.7% DROPS brand · solution	$6.2023 per ML filed eff. 2026-08-19	We don’t know yet
PATADAY TWICE DAILY 0.1% DROPS brand · solution	$2.48198 per ML filed eff. 2026-08-19	We don’t know yet

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-08-19, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $0.8495 per GM filed.

Of the 9 other products in FDA’s Histamine-1 Receptor Antagonist class priced per GM, 3 have a higher middle NADAC price and 6 a lower one. The one in the middle is GS ITCH RELIEF 2%-0.1% CREAM, at $0.0575 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $5.77 for 1 g, at an average of $5.76735 per GM in 2024 (2024-01-01 to 2024-12-31) for “Olopatadine HCl*” and “Olopatadine HCl”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 43,298 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

What is your cash price for 1 g? Is it lower than what I would pay through my insurance?
How much is in the package I am getting? This page uses 1 g; your package may hold a different amount.
If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.

Questions

Why is the comparison with Medicare for OLOPATADINE 665 MCG NASAL SPRY labelled estimated?: Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Olopatadine HCl* / Olopatadine HCl: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's GM. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. All 3 NADAC NDCs the name join matched to it have an FDA route including NASAL.
Why does this page start at 1 g?: The FDA package description of NDC 45802-0104-01 (“1 BOTTLE in 1 CARTON (45802-104-01) / 240 SPRAY in 1 BOTTLE”) does not give one amount in g, NADAC’s unit for this product. So the card starts at 1 GM; change it to match your prescription.

Its pharmacologic classes

Histamine-1 Receptor Antagonist 167 products
Histamine-1 Receptor Inhibitor 17 products
Mast Cell Stabilizer 17 products