PROLIA 60 MG/ML SYRINGE
FDA nonproprietary name: denosumab
For 1 mL
Pharmacies pay
$1,862.74 filed
1 × $1,862.74398 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$1,711.38 filed
1 × $1,711.37983 per ML, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
0.92× estimated
Medicare paid 8% less than pharmacies pay.
Part D averages every strength and form sold under “Prolia” / “Denosumab” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$2,147.15 estimated
$1,862.74 + $279.41 (15%) + $5.00 fee per fill = $2,147.15
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
PROLIA 60 MG/ML SYRINGE is how the CMS NADAC file names this product. The FDA NDC Directory lists it as denosumab, under the trade name “Prolia”.
FDA gives its dosage form as injection and its route as subcutaneous.
The labeler, the company named on the label, is Amgen, Inc.
FDA’s Established Pharmacologic Class for it is RANK Ligand Inhibitor.
The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $1,862.74 for 1 mL (1 × $1,862.74398 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
What NADAC measures · NADAC explanation codes
All 2 NDCs
- 55513-0710-01 · Amgen, Inc · $1,862.74398 per ML · eff. 2026-09-23 filed
- 55513-0710-21 · Amgen, Inc · $1,862.74398 per ML · eff. 2026-09-23 filed
Other strengths, forms and brands
4 other products in the NADAC file share the FDA nonproprietary name denosumab with PROLIA 60 MG/ML SYRINGE.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| BILDYOS 60 MG/ML SYRINGE | $814.13419 per ML filed | $920.16 per ML derived |
| CONEXXENCE 60 MG/ML SYRINGE | $1,740.44875 per ML filed | $1,722.12 per ML derived |
| JUBBONTI 60 MG/ML SYRINGE | $1,536.90512 per ML filed | $1,619.46 per ML derived |
| PROLIA 60 MG/ML SYRINGE this page | $1,862.74398 per ML filed | $1,711.37983 per ML filed |
| XGEVA 120 MG/1.7 ML VIAL | $2,001.51678 per ML filed | $1,850.82154 per ML filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-01-07, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
The middle of its 2 NDCs’ NADAC prices is $1,862.74398 per ML filed.
Of the 5 other products in FDA’s RANK Ligand Inhibitor class priced per ML, 1 has a higher middle NADAC price and 4 a lower one. The one in the middle is STOBOCLO 60 MG/ML SYRINGE, at $1,582.15435 per ML filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $1,711.38 for 1 mL, at an average of $1,711.37983 per ML in 2024 (2024-01-01 to 2024-12-31) for “Prolia” and “Denosumab”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 450,858 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
- How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for PROLIA 60 MG/ML SYRINGE labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Prolia / Denosumab: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
- Why does this page start at 1 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 1 mL in one package for all 2 NDCs of this product (“1 SYRINGE in 1 CARTON (55513-710-01) / 1 mL in 1 SYRINGE”), so the card starts at one package: 1 ML. Change it to match your prescription.