PROMETHAZINE 25 MG SUPPOSITORY
For 1 suppository
Pharmacies pay
$2.03 filed
1 × $2.03477 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare
We don’t know yet
No Medicare reference price. Part D: OpenBill did not match this NDC to a usable Medicare Part D spending row. Either Part D has none for it, or the rows that share its name could not safely be tied to it (for example, they mix units, routes or release forms, or the drug is sold over the counter, which Part D does not cover). Part B: This NDC is not in the current quarter’s Medicare Part B NDC-HCPCS crosswalk, so it has no Part B payment limit.
The spread
We don’t know yet
There is no Medicare figure to compare with, so there is no spread.
Cost-plus estimate
$7.33 estimated
$2.03 + $0.30 (15%) + $5.00 fee per fill = $7.33
This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
PROMETHAZINE 25 MG SUPPOSITORY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as promethazine hydrochloride.
FDA gives its dosage form as suppository and its route as rectal.
Its labelers, the companies named on the label, are Camber Pharmaceuticals, Inc. and Padagis Israel Pharmaceuticals Ltd.
FDA’s Established Pharmacologic Class for it is Phenothiazine.
The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes); the FDA directory lists 2 of them.
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $2.03 for 1 suppository (1 × $2.03477 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.
What NADAC measures · NADAC explanation codes
All 3 NDCs
- 31722-0041-31 · Camber Pharmaceuticals, Inc. · $2.03477 per EA · eff. 2026-09-23 filed
- 45802-0759-00 · not listed as a package in the FDA directory · $2.03477 per EA · eff. 2026-09-23 filed
- 45802-0759-30 · Padagis Israel Pharmaceuticals Ltd · $2.03477 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
12 other products in the NADAC file share the FDA nonproprietary name promethazine hydrochloride with PROMETHAZINE 25 MG SUPPOSITORY.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| PROMETHAZINE 6.25 MG/5 ML SOLN | $0.04198 per ML filed | We don’t know yet |
| PROMETHAZINE 6.25 MG/5 ML SYRP | $0.04198 per ML filed | We don’t know yet |
| PROMETHAZINE 12.5 MG SUPPOS | $1.85416 per EA filed | We don’t know yet |
| PROMETHAZINE 12.5 MG TABLET | $0.05434 per EA filed | We don’t know yet |
| PROMETHAZINE 25 MG SUPPOSITORY this page | $2.03477 per EA filed | We don’t know yet |
| PROMETHAZINE 25 MG TABLET | $0.04548 per EA filed | We don’t know yet |
| PROMETHAZINE 25 MG/ML AMPUL | $1.33454 per ML filed | $1.68532 per ML derived |
| PROMETHAZINE 25 MG/ML VIAL | $1.74825 per ML filed | $1.68532 per ML derived |
| PROMETHAZINE 50 MG TABLET | $0.08196 per EA filed | We don’t know yet |
| PROMETHAZINE 50 MG/ML AMPUL | $2.33887 per ML filed | $3.241 per ML derived |
| PROMETHEGAN 12.5 MG SUPPOS | $1.85416 per EA filed | $5.04452 per EA filed |
| PROMETHEGAN 25 MG SUPPOSITORY | $2.03477 per EA filed | $5.04452 per EA filed |
| PROMETHEGAN 50 MG SUPPOSITORY | $26.69133 per EA filed | $5.04452 per EA filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-05-20, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
The middle of its 3 NDCs’ NADAC prices is $2.03477 per EA filed.
Of the 32 other products in FDA’s Phenothiazine class priced per EA, 3 have a higher middle NADAC price and 28 a lower one; 1 has the same. The one in the middle is CHLORPROMAZINE 50 MG TABLET, at $0.41446 per EA filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
We don’t know yet; the card above says why.
Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 suppository? Is it lower than what I would pay through my insurance?
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why does this page start at 1 suppository?
- NADAC prices this product per EA, and the FDA NDC Directory lists 2 of its 3 NDCs (it does not list the other one) as dosage form “SUPPOSITORY” with route “RECTAL”. Only a tablet, capsule, lozenge or troche with route “ORAL”, or a tablet or film with route “SUBLINGUAL” or “BUCCAL”, starts at 30, and none of these is one. So the card starts at 1 suppository, priced per suppository, rather than guess how many make up a fill; change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- CHLORPROMAZINE 10 MG TABLET
- FLUPHENAZINE 1 MG TABLET
- PERPHENAZINE 16 MG TABLET
- FLUPHENAZINE DEC 125 MG/5 ML
- TRIFLUOPERAZINE 1 MG TABLET