PROMETHEGAN 25 MG SUPPOSITORY
FDA nonproprietary name: promethazine hydrochloride
For 1 suppository
Pharmacies pay
$2.03 filed
1 × $2.03477 per EA
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$5.04 filed
1 × $5.04452 per EA, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
2.5× estimated
Medicare paid 2.5× what pharmacies pay.
Part D averages every strength and form sold under “Promethegan” / “Promethazine HCl” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$7.33 estimated
$2.03 + $0.30 (15%) + $5.00 fee per fill = $7.33
This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
PROMETHEGAN 25 MG SUPPOSITORY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as promethazine hydrochloride, under the trade name “PROMETHEGAN”.
FDA gives its dosage form as suppository and its route as rectal.
The labeler, the company named on the label, is Cosette Pharmaceuticals, Inc.
FDA’s Established Pharmacologic Class for it is Phenothiazine.
The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes); the FDA directory lists 1 of them.
NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $2.03 for 1 suppository (1 × $2.03477 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.
What NADAC measures · NADAC explanation codes
All 2 NDCs
- 00713-0526-06 · not listed as a package in the FDA directory · $2.03477 per EA · eff. 2026-09-23 filed
- 00713-0526-12 · Cosette Pharmaceuticals, Inc. · $2.03477 per EA · eff. 2026-09-23 filed
Other strengths, forms and brands
12 other products in the NADAC file share the FDA nonproprietary name promethazine hydrochloride with PROMETHEGAN 25 MG SUPPOSITORY.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| PROMETHAZINE 6.25 MG/5 ML SOLN | $0.04198 per ML filed | We don’t know yet |
| PROMETHAZINE 6.25 MG/5 ML SYRP | $0.04198 per ML filed | We don’t know yet |
| PROMETHAZINE 12.5 MG SUPPOS | $1.85416 per EA filed | We don’t know yet |
| PROMETHAZINE 12.5 MG TABLET | $0.05434 per EA filed | We don’t know yet |
| PROMETHAZINE 25 MG SUPPOSITORY | $2.03477 per EA filed | We don’t know yet |
| PROMETHAZINE 25 MG TABLET | $0.04548 per EA filed | We don’t know yet |
| PROMETHAZINE 25 MG/ML AMPUL | $1.33454 per ML filed | $1.68532 per ML derived |
| PROMETHAZINE 25 MG/ML VIAL | $1.74825 per ML filed | $1.68532 per ML derived |
| PROMETHAZINE 50 MG TABLET | $0.08196 per EA filed | We don’t know yet |
| PROMETHAZINE 50 MG/ML AMPUL | $2.33887 per ML filed | $3.241 per ML derived |
| PROMETHEGAN 12.5 MG SUPPOS | $1.85416 per EA filed | $5.04452 per EA filed |
| PROMETHEGAN 25 MG SUPPOSITORY this page | $2.03477 per EA filed | $5.04452 per EA filed |
| PROMETHEGAN 50 MG SUPPOSITORY | $26.69133 per EA filed | $5.04452 per EA filed |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-05-20, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
The middle of its 2 NDCs’ NADAC prices is $2.03477 per EA filed.
Of the 32 other products in FDA’s Phenothiazine class priced per EA, 3 have a higher middle NADAC price and 28 a lower one; 1 has the same. The one in the middle is CHLORPROMAZINE 50 MG TABLET, at $0.41446 per EA filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $5.04 for 1 suppository, at an average of $5.04452 per EA in 2024 (2024-01-01 to 2024-12-31) for “Promethegan” and “Promethazine HCl”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 18,532 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 suppository? Is it lower than what I would pay through my insurance?
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for PROMETHEGAN 25 MG SUPPOSITORY labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Promethegan / Promethazine HCl: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on brand name.
- Why does this page start at 1 suppository?
- NADAC prices this product per EA, and the FDA NDC Directory lists 1 of its 2 NDCs (it does not list the other one) as dosage form “SUPPOSITORY” with route “RECTAL”. Only a tablet, capsule, lozenge or troche with route “ORAL”, or a tablet or film with route “SUBLINGUAL” or “BUCCAL”, starts at 30, and this is not one. So the card starts at 1 suppository, priced per suppository, rather than guess how many make up a fill; change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- CHLORPROMAZINE 10 MG TABLET
- FLUPHENAZINE 1 MG TABLET
- PERPHENAZINE 16 MG TABLET
- FLUPHENAZINE DEC 125 MG/5 ML
- TRIFLUOPERAZINE 1 MG TABLET