PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP

What it is

PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP is how the CMS NADAC file names this product. The FDA NDC Directory lists it as promethazine hydrochloride and dextromethorphan hydrobromide.

FDA gives its dosage form as syrup and its route as oral.

The labeler, the company named on the label, is Xttrium Laboratories, Inc.

FDA lists it under 3 Established Pharmacologic Classes: Phenothiazine, Sigma-1 Agonist and Uncompetitive N-methyl-D-aspartate Receptor Antagonist.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00116-4024-16.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $18.47 for 473 mL (473 × $0.03904 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

The NDC

• 00116-4024-16 · Xttrium Laboratories, Inc · $0.03904 per ML · eff. 2026-09-23 filed

Other strengths, forms and brands

1 other product in the NADAC file shares the FDA nonproprietary name promethazine hydrochloride and dextromethorphan hydrobromide with PROMETHAZINE-DM 6.25-15 MG/5 ML SYRUP.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

Its NADAC price is $0.03904 per ML filed.

Of the 8 other products in FDA’s Phenothiazine class priced per ML, 7 have a higher middle NADAC price and 0 a lower one; 1 has the same. The one in the middle is PROMETHAZINE-CODEINE SOLUTION, at $0.06967 per ML filed (eff. 2026-09-23).

Of the 63 other products in FDA’s Sigma-1 Agonist class priced per ML, 24 have a higher middle NADAC price and 38 a lower one; 1 has the same. The one in the middle is GNP TUSSIN LONG-ACTING LIQUID, at $0.02263 per ML filed (eff. 2026-09-23).

Of the 63 other products in FDA’s Uncompetitive N-methyl-D-aspartate Receptor Antagonist class priced per ML, 24 have a higher middle NADAC price and 38 a lower one; 1 has the same. The one in the middle is GNP TUSSIN LONG-ACTING LIQUID, at $0.02263 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $23.82 for 473 mL, at an average of $0.05036 per ML in 2024 (2024-01-01 to 2024-12-31) for “Promethazine-DM” and “Promethazine/Dextromethorphan”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 13,336 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 473 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 473 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.