PROMETHAZINE-CODEINE SOLUTION

What it is

PROMETHAZINE-CODEINE SOLUTION is how the CMS NADAC file names this product. The FDA NDC Directory lists it as promethazine hydrochloride and codeine phosphate.

FDA gives its dosage form as solution and its route as oral.

Its labelers, the companies named on the label, are Cosette Pharmaceuticals, Inc., Cranbury Pharmaceuticals, LLC and QUAGEN PHARMACEUTICALS LLC.

FDA lists it under 2 Established Pharmacologic Classes: Opioid Agonist and Phenothiazine.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $32.95 for 473 mL (473 × $0.06967 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

All 3 NDCs

• 00713-0823-75 · Cosette Pharmaceuticals, Inc. · $0.06967 per ML · eff. 2026-09-23 filed
• 27808-0065-02 · Cranbury Pharmaceuticals, LLC · $0.06967 per ML · eff. 2026-09-23 filed
• 70752-0139-12 · QUAGEN PHARMACEUTICALS LLC · $0.06967 per ML · eff. 2026-09-23 filed

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $0.06967 per ML filed.

Of the 31 other products in FDA’s Opioid Agonist class priced per ML, 24 have a higher middle NADAC price and 7 a lower one. The one in the middle is ACETAMINOPHEN-CODEINE 120 MG-12 MG/5 ML SOLUTION, at $0.46877 per ML filed (eff. 2026-09-23).

Of the 8 other products in FDA’s Phenothiazine class priced per ML, 4 have a higher middle NADAC price and 4 a lower one. The one in the middle is PROMETHAZINE 6.25 MG/5 ML SYRP, at $0.04198 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $26.17 for 473 mL, at an average of $0.05534 per ML in 2024 (2024-01-01 to 2024-12-31) for “Promethazine-Codeine” and “Promethazine HCl/Codeine”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 1,137 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 473 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 473 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.