TWYNEO 0.1%-3% CREAM PUMP

What it is

TWYNEO 0.1%-3% CREAM PUMP is how the CMS NADAC file names this product. The FDA NDC Directory lists it as “benzoyl peroxide and tretinoin” and “tretinoin and benzoyl peroxide”, as its NDCs’ listings variously write the nonproprietary name, under the trade name “TWYNEO”.

FDA gives its dosage form as cream and its route as topical.

Its labelers, the companies named on the label, are Galderma Laboratories, L.P. and Mayne Pharma Commercial LLC.

FDA’s Established Pharmacologic Class for it is Retinoid.

The NADAC file of 2026-10-14 prices it under 2 NDCs (National Drug Codes).

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $949.70 for 30 g (30 × $31.6568 per GM, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-08-01. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 4, carried forward from the previous file; 5, calculated based on package size.

The NADAC of all 2 NDCs was carried forward from an earlier file (NADAC explanation code 2 or 4), not newly surveyed: those prices took effect on 2026-08-01. The file is new; the price is not.

What NADAC measures · NADAC explanation codes · Carried-forward prices

All 2 NDCs

• 00299-5945-30 · Galderma Laboratories, L.P. · $31.6568 per GM · eff. 2026-08-01 filed carried forward
• 51862-0771-30 · Mayne Pharma Commercial LLC · $31.6568 per GM · eff. 2026-08-01 filed carried forward

Compared with its class

The middle of its 2 NDCs’ NADAC prices is $31.6568 per GM filed.

Of the 23 other products in FDA’s Retinoid class priced per GM, 0 have a higher middle NADAC price and 23 a lower one. The one in the middle is TRETINOIN 0.025% GEL, at $2.50019 per GM filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-08-01, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $448.55 for 30 g, at an average of $14.95157 per GM in 2024 (2024-01-01 to 2024-12-31) for “Twyneo” and “Tretinoin/Benzoyl Peroxide”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 88 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 30 g? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 30 g; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.