DEPO-MEDROL 80 MG/ML VIAL
FDA nonproprietary name: methylprednisolone acetate
For 1 mL
Pharmacies pay
$11.66 filed
1 × $11.65735 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D paid
$15.58 filed
1 × $15.57632 per ML, Part D average
Medicare's price is not your price.
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
The spread
1.3× estimated
Medicare paid 1.3× what pharmacies pay.
Part D averages every strength and form sold under “Depo-Medrol” / “Methylprednisolone Acetate” into one figure, so it is not specific to this NDC.
OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)
Cost-plus estimate
$18.41 estimated
$11.66 + $1.75 (15%) + $5.00 fee per fill = $18.41
This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
DEPO-MEDROL 80 MG/ML VIAL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as methylprednisolone acetate, under the trade name “Depo-Medrol”.
FDA gives its dosage form as injection, suspension and its route as intra-articular; intralesional; intramuscular; soft tissue.
The labeler, the company named on the label, is Pharmacia & Upjohn Company LLC.
FDA’s Established Pharmacologic Class for it is Corticosteroid.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 00009-3475-01.
NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.
What pharmacies pay
Pharmacies pay $11.66 for 1 mL (1 × $11.65735 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
NADAC also lists, on the row of one brand NDC, what pharmacies pay for the generic equivalent, a different product: $11.92429 per ML filed.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-07-22 · as of 2026-10-14 · retrieved 2026-10-17
What NADAC measures · NADAC explanation codes
The NDC
- 00009-3475-01 · Pharmacia & Upjohn Company LLC · $11.65735 per ML · eff. 2026-09-23 filed
Other strengths, forms and brands
4 other products in the NADAC file share the FDA nonproprietary name methylprednisolone acetate with DEPO-MEDROL 80 MG/ML VIAL.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| DEPO-MEDROL 40 MG/ML VIAL | $6.82706 per ML filed | $15.57632 per ML filed |
| DEPO-MEDROL 80 MG/ML VIAL this page | $11.65735 per ML filed | $15.57632 per ML filed |
| METHYLPREDNISOLONE 40 MG/ML VL | $7.49 per ML filed | $4.92 per ML derived |
| METHYLPREDNISOLONE 80 MG/ML VL | $11.92429 per ML filed | $9.84 per ML derived |
| METHYLPREDNISOLONE 400 MG/10 ML | $5.8078 per ML filed | $4.92 per ML derived |
Part D is one average per brand and generic name, over every strength and form.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-04-22, 2026-07-22, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18
OpenBill calculation · october-2026-medicare-part-b-payment-limit-files-final.zip + october-2026-ndc-hcpcs-crosswalk-final.zip · Part B limit 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18) · Part B crosswalk 2026-10-01 to 2026-12-31 (file of 2026-09-17, retrieved 2026-10-18)
Compared with its class
Its NADAC price is $11.65735 per ML filed.
Of the 106 other products in FDA’s Corticosteroid class priced per ML, 19 have a higher middle NADAC price and 87 a lower one. The one in the middle is FLUNISOLIDE 0.025% SPRAY, at $1.98777 per ML filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
Medicare Part D paid $15.58 for 1 mL, at an average of $15.57632 per ML in 2024 (2024-01-01 to 2024-12-31) for “Depo-Medrol” and “Methylprednisolone Acetate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).
That average covers 914 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.
Medicare's price is not your price.
What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
- Is a generic version available, and would it suit me? NADAC lists a generic with the same ingredient, strength and dosage form by FDA: METHYLPREDNISOLONE 80 MG/ML VL. Ask your pharmacist or prescriber; do not switch on your own.
- How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
- If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why is the comparison with Medicare for DEPO-MEDROL 80 MG/ML VIAL labelled estimated?
- Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Depo-Medrol / Methylprednisolone Acetate: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on brand name.
- Why does this page start at 1 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 1 mL in one package for this product’s NDC (“1 VIAL, SINGLE-DOSE in 1 PACKAGE (0009-3475-01) / 1 mL in 1 VIAL, SINGLE-DOSE”), so the card starts at one package: 1 ML. Change it to match your prescription.
Related pages
Its pharmacologic class
Related in the same class
- PREDNISONE 1 MG TABLET
- TRELEGY ELLIPTA 100-62.5-25
- METHYLPREDNISOLONE 16 MG TAB
- PREDNISOLONE AC 1% EYE DROP
- BREO ELLIPTA 100-25 MCG INHALR