Why is the comparison with Medicare for EPINEPHRINE 0.15 MG AUTO-INJCT labelled estimated?

Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Epinephrine / Epinephrine: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name. 12 of 13 NADAC NDCs joined to this name are priced per EA (1 per ML): CMS's average mixes those units.

Why does this page start at 1 unit (EA)?

NADAC prices this product per EA, and the FDA NDC Directory lists 4 of its 6 NDCs (it does not list the other 2) as dosage form “INJECTION” with routes “INTRAMUSCULAR”, “INTRAMUSCULAR; SUBCUTANEOUS”, “SUBCUTANEOUS”. Only a tablet, capsule, lozenge or troche with route “ORAL”, or a tablet or film with route “SUBLINGUAL” or “BUCCAL”, starts at 30, and none of these is one. NADAC’s EA for it may be a whole package (such as a kit, pen, syringe, vial or inhaler) or one dose inside it, and the files do not say which. So the card starts at 1 unit (EA) rather than guess how many make up a fill; change it to match your prescription.

EPINEPHRINE 0.15 MG AUTO-INJCT

For 1 unit (EA)

Pharmacies pay

$117.97 – $141.88 filed

1 × $117.96603 to $141.88177 per EA (the 6 NDCs differ)

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D paid

$99.63 filed

1 × $99.62948 per EA, Part D average

Medicare's price is not your price.

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

The spread

0.70× – 0.84× estimated

Medicare paid between 0.70× and 0.84× what pharmacies pay, depending on the NDC.

Part D averages every strength and form sold under “Epinephrine” into one figure, so it is not specific to this NDC.

OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)

Cost-plus estimate

$140.67 – $168.16 estimated

NADAC for the pack + 15% + $5.00 fee per fill

This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out

OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)

Open the interactive card Change the quantity, type what you were charged, and see every record in full.

What it is

EPINEPHRINE 0.15 MG AUTO-INJCT is how the CMS NADAC file names this product. The FDA NDC Directory lists it as epinephrine.

FDA gives its dosage form as injection and its route as “intramuscular; subcutaneous”, “subcutaneous” and “intramuscular”.

Its labelers, the companies named on the label, are Teva Pharmaceuticals USA, Inc., Amneal Pharmaceuticals of New York LLC and Viatris Specialty LLC.

FDA lists it under 3 Established Pharmacologic Classes: alpha-Adrenergic Agonist, beta-Adrenergic Agonist and Catecholamine.

The NADAC file of 2026-10-14 prices it under 6 NDCs (National Drug Codes); the FDA directory lists 4 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $117.97 – $141.88 for 1 unit (EA), depending on the NDC ($117.96603 to $141.88177 per EA), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 6, the CMS Covered Outpatient Drug Product File S/I/N drug category was not applied when grouping drugs for the calculation.

What NADAC measures · NADAC explanation codes

All 6 NDCs

00093-5985-19 · not listed as a package in the FDA directory · $129.05328 per EA · eff. 2026-09-23 filed
00093-5985-27 · Teva Pharmaceuticals USA, Inc. · $129.05328 per EA · eff. 2026-09-23 filed
00115-1695-30 · Amneal Pharmaceuticals of New York LLC · $117.96603 per EA · eff. 2026-09-23 filed
00115-1695-49 · Amneal Pharmaceuticals of New York LLC · $117.96603 per EA · eff. 2026-09-23 filed
49502-0101-01 · not listed as a package in the FDA directory · $141.88177 per EA · eff. 2026-09-23 filed
49502-0101-02 · Viatris Specialty LLC · $141.88177 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

8 other products in the NADAC file share the FDA nonproprietary name epinephrine with EPINEPHRINE 0.15 MG AUTO-INJCT.

Product	Pharmacies pay per unit	Medicare per unit
ADRENALIN 1 MG/ML VIAL brand · injection	$7.79554 per ML filed eff. 2025-10-28	$13.74495 per ML filed Part D 2024 average
AUVI-Q 0.1 MG AUTO-INJECTOR brand · injection, solution	$309.55227 per EA filed eff. 2026-07-01	$300.57204 per EA filed Part D 2024 average
AUVI-Q 0.15 MG AUTO-INJECTOR brand · injection, solution	$309.85103 per EA filed eff. 2026-07-01	$300.57204 per EA filed Part D 2024 average
AUVI-Q 0.3 MG AUTO-INJECTOR brand · injection, solution	$309.37573 per EA filed eff. 2026-07-01	$300.57204 per EA filed Part D 2024 average
EPINEPHRINE 0.15 MG AUTO-INJCT this page generic · injection	$117.96603 to $141.88177 per EA filed eff. 2026-09-23	$99.62948 per EA filed Part D 2024 average
EPINEPHRINE 0.3 MG AUTO-INJECT generic · injection	$111.99764 to $141.27567 per EA filed eff. 2026-09-23	$99.62948 per EA filed Part D 2024 average
EPINEPHRINE 1 MG/10 ML LUERJET generic · injection	$1.23804 per ML filed eff. 2026-09-23	We don’t know yet
NEFFY 1 MG/0.1 ML NASAL SPRAY brand · spray	$360.13761 per EA filed eff. 2026-09-23	$340.89238 per EA filed Part D 2024 average
NEFFY 2 MG/0.1 ML NASAL SPRAY brand · spray	$359.49229 per EA filed eff. 2026-09-23	$340.89238 per EA filed Part D 2024 average

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2025-10-28, 2026-07-01, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 6 NDCs’ NADAC prices is $129.05328 per EA filed.

Of the 59 other products in FDA’s alpha-Adrenergic Agonist class priced per EA, 6 have a higher middle NADAC price and 53 a lower one. The one in the middle is FEXOFENADINE-PSE ER 60-120 TAB, at $0.48321 per EA filed (eff. 2026-09-23).

Of the 6 other products in FDA’s beta-Adrenergic Agonist class priced per EA, 6 have a higher middle NADAC price and 0 a lower one. The one in the middle is AUVI-Q 0.1 MG AUTO-INJECTOR, at $309.55227 per EA filed (eff. 2026-07-01).

Of the 6 other products in FDA’s Catecholamine class priced per EA, 6 have a higher middle NADAC price and 0 a lower one. The one in the middle is AUVI-Q 0.1 MG AUTO-INJECTOR, at $309.55227 per EA filed (eff. 2026-07-01).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-07-01, 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $99.63 for 1 unit (EA), at an average of $99.62948 per EA in 2024 (2024-01-01 to 2024-12-31) for “Epinephrine”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 578,447 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

What is your cash price for 1 unit (EA)? Is it lower than what I would pay through my insurance?
Which NDC (the 11-digit number on the package) is this? Pharmacies pay $117.96603 to $141.88177 per EA for this product, depending on the NDC.
If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.

Questions

Why is the comparison with Medicare for EPINEPHRINE 0.15 MG AUTO-INJCT labelled estimated?: Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Epinephrine / Epinephrine: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's EA. Joined on generic name. 12 of 13 NADAC NDCs joined to this name are priced per EA (1 per ML): CMS's average mixes those units.
Why does this page start at 1 unit (EA)?: NADAC prices this product per EA, and the FDA NDC Directory lists 4 of its 6 NDCs (it does not list the other 2) as dosage form “INJECTION” with routes “INTRAMUSCULAR”, “INTRAMUSCULAR; SUBCUTANEOUS”, “SUBCUTANEOUS”. Only a tablet, capsule, lozenge or troche with route “ORAL”, or a tablet or film with route “SUBLINGUAL” or “BUCCAL”, starts at 30, and none of these is one. NADAC’s EA for it may be a whole package (such as a kit, pen, syringe, vial or inhaler) or one dose inside it, and the files do not say which. So the card starts at 1 unit (EA) rather than guess how many make up a fill; change it to match your prescription.