ITCH RELIEF 2%-0.1% SPRAY
FDA nonproprietary name: diphenhydramine hcl, zinc acetate
For 59 mL
Pharmacies pay
$2.78 filed
59 × $0.04712 per ML
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Medicare
We don’t know yet
No Medicare reference price. Part D: OpenBill did not match this NDC to a usable Medicare Part D spending row. Either Part D has none for it, or the rows that share its name could not safely be tied to it (for example, they mix units, routes or release forms, or the drug is sold over the counter, which Part D does not cover). Part B: This NDC is not in the current quarter’s Medicare Part B NDC-HCPCS crosswalk, so it has no Part B payment limit.
The spread
We don’t know yet
There is no Medicare figure to compare with, so there is no spread.
Cost-plus estimate
$8.20 estimated
$2.78 + $0.42 (15%) + $5.00 fee per fill = $8.20
This is a model, not a price any pharmacy quoted. Shipping is not included. For a pack this cheap, the $5.00 fee is most of the estimate. How it is worked out
OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)
Open the interactive card Change the quantity, type what you were charged, and see every record in full.
What it is
ITCH RELIEF 2%-0.1% SPRAY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as diphenhydramine hcl, zinc acetate, under the trade name “Itch Relief”.
FDA gives its dosage form as spray and its route as topical.
The labeler, the company named on the label, is Cardinal Health, 110 dba Leader.
FDA lists it under 2 Established Pharmacologic Classes: Copper Absorption Inhibitor and Histamine-1 Receptor Antagonist.
The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 70000-0023-01.
NADAC classes it as a generic drug (rate-setting class G), and marks it as sold over the counter.
What pharmacies pay
Pharmacies pay $2.78 for 59 mL (59 × $0.04712 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.
NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.
What NADAC measures · NADAC explanation codes
The NDC
- 70000-0023-01 · Cardinal Health, 110 dba Leader · $0.04712 per ML · eff. 2026-09-23 filed
Other strengths, forms and brands
1 other product in the NADAC file shares the FDA nonproprietary name diphenhydramine hcl, zinc acetate with ITCH RELIEF 2%-0.1% SPRAY.
| Product | Pharmacies pay per unit | Medicare per unit |
|---|---|---|
| GNP ITCH RELIEF 2%-0.1% SPRAY | $0.04712 per ML filed | We don’t know yet |
| ITCH RELIEF 2%-0.1% SPRAY this page | $0.04712 per ML filed | We don’t know yet |
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
Compared with its class
Its NADAC price is $0.04712 per ML filed.
Of the 11 other products in FDA’s Copper Absorption Inhibitor class priced per ML, 0 have a higher middle NADAC price and 10 a lower one; 1 has the same. The one in the middle is CALDYPHEN CLEAR LOTION, at $0.01318 per ML filed (eff. 2026-09-23).
Of the 46 other products in FDA’s Histamine-1 Receptor Antagonist class priced per ML, 24 have a higher middle NADAC price and 21 a lower one; 1 has the same. The one in the middle is ED-A-HIST DM LIQUID, at $0.06691 per ML filed (eff. 2026-09-23).
Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.
CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17
What Medicare paid
We don’t know yet; the card above says why.
Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched
What to ask at the counter
None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.
- What is your cash price for 59 mL? Is it lower than what I would pay through my insurance?
- It is sold over the counter, so shelf prices vary from store to store: what does it cost per unit here?
- How much is in the package I am getting? This page uses 59 mL; your package may hold a different amount.
- These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.
Questions
- Why does this page start at 59 mL?
- NADAC prices this product per ML. The FDA NDC Directory’s package description gives 59 mL in one package for this product’s NDC (“59 mL in 1 BOTTLE, SPRAY (70000-0023-1)”), so the card starts at one package: 59 ML. Change it to match your prescription.
Related pages
Its pharmacologic classes
Related in the same class
- ANTI-ITCH 2%-0.1% CREAM
- AZELASTINE 0.1% (137 MCG) SPRY
- DESLORATADINE 5 MG TABLET
- DIPHENHYDRAMINE 50 MG/ML VIAL
- BEPOTASTINE 1.5% EYE DROP