DIPHENHYDRAMINE 50 MG/ML VIAL

What it is

DIPHENHYDRAMINE 50 MG/ML VIAL is how the CMS NADAC file names this product. The FDA NDC Directory lists it as diphenhydramine hydrochloride, under the trade name “DIPHENHYDRAMINE”.

FDA gives its dosage form as “injection” and “injection, solution” and its route as intramuscular; intravenous.

FDA lists 7 labelers (the companies named on the label) for its NDCs, among them Hikma Pharmaceuticals USA Inc., Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc. and Sagent Pharmaceuticals.

FDA’s Established Pharmacologic Class for it is Histamine-1 Receptor Antagonist.

The NADAC file of 2026-10-14 prices it under 10 NDCs (National Drug Codes).

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $0.90 – $1.05 for 1 mL, depending on the NDC ($0.89801 to $1.0542 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

The 7 labelers

Other strengths, forms and brands

24 other products in the NADAC file share the FDA nonproprietary name diphenhydramine hydrochloride with DIPHENHYDRAMINE 50 MG/ML VIAL. The 23 below share a strength or dosage form with it first; search OpenBill for the rest.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 10 NDCs’ NADAC prices is $0.89801 per ML filed.

Of the 46 other products in FDA’s Histamine-1 Receptor Antagonist class priced per ML, 17 have a higher middle NADAC price and 29 a lower one. The one in the middle is ITCH RELIEF 2%-0.1% SPRAY, at $0.04712 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $1.24 for 1 mL, at an average of $1.23688 per ML in 2024 (2024-01-01 to 2024-12-31) for “Diphenhydramine HCl*” and “Diphenhydramine HCl”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 61,123 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
• Which NDC (the 11-digit number on the package) is this? Pharmacies pay $0.89801 to $1.0542 per ML for this product, depending on the NDC.
• How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.