Why is the comparison with Medicare for NALOXONE 2 MG/2 ML SYRINGE labelled estimated?

Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Naloxone HCl* / Naloxone HCl: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. Only NADAC NDCs whose FDA route includes INTRAMUSCULAR and INTRAVENOUS and SUBCUTANEOUS point at this name (19 of the 27 the name join matched); NDCs of another route or with no known FDA route do not. 3 of the 19 NDCs that point at this name are not listed in the FDA NDC Directory as packages of their own; their route was taken from FDA's record for the same product (labeler and product code).

Why does this page start at 1 mL?

The FDA package descriptions of this product’s NDCs give different amounts (2 mL, 20 mL). So the card starts at 1 ML; change it to match your prescription.

NALOXONE 2 MG/2 ML SYRINGE

For 1 mL

Pharmacies pay

$6.27 – $12.74 filed

1 × $6.27129 to $12.74097 per ML (the 14 NDCs differ)

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D paid

$30.90 filed

1 × $30.89639 per ML, Part D average

Medicare's price is not your price.

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

The spread

2.4× – 4.9× estimated

Medicare paid between 2.4× and 4.9× what pharmacies pay, depending on the NDC.

Part D averages every strength and form sold under “Naloxone HCl*” / “Naloxone HCl” into one figure, so it is not specific to this NDC.

OpenBill calculation · DSD_PTD_RY26_P04_V10_DY24_BGM.csv + nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17) · Part D 2024-01-01 to 2024-12-31 (file of 2026-06-25, retrieved 2026-10-18)

Cost-plus estimate

$12.21 – $19.65 estimated

NADAC for the pack + 15% + $5.00 fee per fill

This is a model, not a price any pharmacy quoted. Shipping is not included. How it is worked out

OpenBill calculation · nadac-national-average-drug-acquisition-cost-20261014.csv · NADAC eff. 2026-09-23 (file of 2026-10-14, retrieved 2026-10-17)

Open the interactive card Change the quantity, type what you were charged, and see every record in full.

What it is

NALOXONE 2 MG/2 ML SYRINGE is how the CMS NADAC file names this product. The FDA NDC Directory lists it as naloxone hydrochloride.

FDA gives its dosage form as “injection” and “injection, solution” and its route as “intramuscular; intravenous; subcutaneous” and “parenteral”.

FDA lists 7 labelers (the companies named on the label) for its NDCs, among them Hikma Pharmaceuticals USA Inc., Par Health USA, LLC and Baxter Healthcare Corporation.

FDA’s Established Pharmacologic Class for it is Opioid Antagonist.

The NADAC file of 2026-10-14 prices it under 14 NDCs (National Drug Codes); the FDA directory lists 11 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $6.27 – $12.74 for 1 mL, depending on the NDC ($6.27129 to $12.74097 per ML), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

The 7 labelers

Labeler	NDCs	Pharmacies pay per unit
International Medication Systems, Limited	3	$12.74097 per ML filed
Dr. Reddy's Laboratories, Inc.	2	$6.27129 to $12.74097 per ML filed
Eugia US LLC	2	$6.27129 to $12.74097 per ML filed
Baxter Healthcare Corporation	1	$12.74097 per ML filed
Hikma Pharmaceuticals USA Inc.	1	$12.74097 per ML filed
Mylan Institutional LLC	1	$6.27129 per ML filed
Par Health USA, LLC	1	$6.27129 per ML filed
Not listed as a package in the FDA directory	3	$6.27129 per ML filed

All 14 NDCs, with labeler and price

00641-6205-01 · not listed as a package in the FDA directory · $6.27129 per ML · eff. 2026-09-23 filed
00641-6205-10 · Hikma Pharmaceuticals USA Inc. · $12.74097 per ML · eff. 2026-09-23 filed
42023-0224-01 · Par Health USA, LLC · $6.27129 per ML · eff. 2026-09-23 filed
43066-0142-01 · not listed as a package in the FDA directory · $6.27129 per ML · eff. 2026-09-23 filed
43066-0142-10 · Baxter Healthcare Corporation · $12.74097 per ML · eff. 2026-09-23 filed
43598-0750-10 · Dr. Reddy's Laboratories, Inc. · $12.74097 per ML · eff. 2026-09-23 filed
43598-0750-11 · Dr. Reddy's Laboratories, Inc. · $6.27129 per ML · eff. 2026-09-23 filed
55150-0345-01 · Eugia US LLC · $6.27129 per ML · eff. 2026-09-23 filed
55150-0345-10 · Eugia US LLC · $12.74097 per ML · eff. 2026-09-23 filed
67457-0992-02 · Mylan Institutional LLC · $6.27129 per ML · eff. 2026-09-23 filed
76045-0112-01 · not listed as a package in the FDA directory · $6.27129 per ML · eff. 2026-09-23 filed
76329-1469-01 · International Medication Systems, Limited · $12.74097 per ML · eff. 2026-09-23 filed
76329-3369-01 · International Medication Systems, Limited · $12.74097 per ML · eff. 2026-09-23 filed
76329-3469-01 · International Medication Systems, Limited · $12.74097 per ML · eff. 2026-09-23 filed

Other strengths, forms and brands

5 other products in the NADAC file share the FDA nonproprietary name naloxone hydrochloride with NALOXONE 2 MG/2 ML SYRINGE.

Product	Pharmacies pay per unit	Medicare per unit
FT NALOXONE HCL 4 MG NASAL SPR generic · spray	$17.17734 per EA filed eff. 2026-09-23	We don’t know yet
GNP NALOXONE HCL 4 MG NASAL SP generic · spray	$17.17734 per EA filed eff. 2026-09-23	We don’t know yet
NALOXONE 0.4 MG/ML VIAL generic · injection, solution	$3.82425 per ML filed eff. 2026-09-23	$30.89639 per ML filed Part D 2024 average
NALOXONE 2 MG/2 ML SYRINGE this page generic · injection / injection, solution	$6.27129 to $12.74097 per ML filed eff. 2026-09-23	$30.89639 per ML filed Part D 2024 average
NALOXONE 4 MG/10 ML VIAL generic · injection, solution	$3.82425 per ML filed eff. 2026-09-23	$30.89639 per ML filed Part D 2024 average
NALOXONE HCL 4 MG NASAL SPRAY generic · spray, metered / spray	$17.17734 per EA filed eff. 2026-09-23	We don’t know yet

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

What Medicare paid

Medicare Part D paid $30.90 for 1 mL, at an average of $30.89639 per ML in 2024 (2024-01-01 to 2024-12-31) for “Naloxone HCl*” and “Naloxone HCl”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 715,410 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

10 of the product’s 14 NDCs have this Medicare figure; the other 4 do not, and the interactive card says why for each.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
Which NDC (the 11-digit number on the package) is this? Pharmacies pay $6.27129 to $12.74097 per ML for this product, depending on the NDC.
How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.

Questions

Why is the comparison with Medicare for NALOXONE 2 MG/2 ML SYRINGE labelled estimated?: Beyond what the card shows, the records give these reasons: The Part D figure covers 2024-01-01 to 2024-12-31; the NADAC price is from the file of 2026-10-14. Part D spending basis, as the Part D record states it: Part D 2024 average spend per dosage unit for Naloxone HCl* / Naloxone HCl: all makers, strengths, forms and routes combined, claim-weighted; gross cost incl. dispensing fees and patient pay, before rebates. Unit taken as NADAC's ML. Joined on generic name. *: CMS says this average reflects multiple routes of administration, which may have different unit prices. Only NADAC NDCs whose FDA route includes INTRAMUSCULAR and INTRAVENOUS and SUBCUTANEOUS point at this name (19 of the 27 the name join matched); NDCs of another route or with no known FDA route do not. 3 of the 19 NDCs that point at this name are not listed in the FDA NDC Directory as packages of their own; their route was taken from FDA's record for the same product (labeler and product code).
Why does this page start at 1 mL?: The FDA package descriptions of this product’s NDCs give different amounts (2 mL, 20 mL). So the card starts at 1 ML; change it to match your prescription.

Its pharmacologic class

Opioid Antagonist 34 products