PRISTIQ ER 50 MG TABLET

What it is

PRISTIQ ER 50 MG TABLET is how the CMS NADAC file names this product. The FDA NDC Directory lists it as desvenlafaxine succinate, under the trade name “Pristiq Extended-Release”.

FDA gives its dosage form as tablet, extended release and its route as oral.

The labeler, the company named on the label, is Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.

FDA’s Established Pharmacologic Class for it is Serotonin and Norepinephrine Reuptake Inhibitor.

The NADAC file of 2026-10-14 prices it under 3 NDCs (National Drug Codes).

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $418.90 for 30 tablets (30 × $13.96336 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.

NADAC also lists, on the row of its brand NDCs, what pharmacies pay for the generic equivalent, a different product: $0.39649 per EA filed.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

What NADAC measures · Why 30 tablets · NADAC explanation codes

All 3 NDCs

• 00008-1211-01 · Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. · $13.96336 per EA · eff. 2026-09-23 filed
• 00008-1211-14 · Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. · $13.96336 per EA · eff. 2026-09-23 filed
• 00008-1211-30 · Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc. · $13.96336 per EA · eff. 2026-09-23 filed

Other strengths, forms and brands

5 other products in the NADAC file share the FDA nonproprietary name desvenlafaxine succinate with PRISTIQ ER 50 MG TABLET.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

The middle of its 3 NDCs’ NADAC prices is $13.96336 per EA filed.

Of the 43 other products in FDA’s Serotonin and Norepinephrine Reuptake Inhibitor class priced per EA, 8 have a higher middle NADAC price and 35 a lower one. The one in the middle is MILNACIPRAN HCL 50 MG TABLET, at $2.80179 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

We don’t know yet; the card above says why.

Which Medicare figure OpenBill compares · How Part D is matched · How Part B is matched

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
• Is a generic version available, and would it suit me? NADAC lists a generic with the same ingredient, strength and dosage form by FDA: DESVENLAFAXINE SUCCNT ER 50 MG. Ask your pharmacist or prescriber; do not switch on your own.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.