TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB

What it is

TRAMADOL-ACETAMINOPHEN 37.5-325 MG TAB is how the CMS NADAC file names this product. The FDA NDC Directory lists it as tramadol hydrochloride and acetaminophen.

FDA gives its dosage form as “tablet” and “tablet, film coated” and its route as oral.

Its labelers, the companies named on the label, are AvPAK, Amneal Pharmaceuticals of New York LLC and Aurobindo Pharma Limited.

FDA’s Established Pharmacologic Class for it is Opioid Agonist.

The NADAC file of 2026-10-14 prices it under 7 NDCs (National Drug Codes); the FDA directory lists 6 of them.

NADAC classes it as a generic drug (rate-setting class G), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $3.48 for 30 tablets (30 × $0.11595 per EA, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation code for it: 1, calculated from the most recently completed pharmacy survey.

What NADAC measures · Why 30 tablets · NADAC explanation codes

The 3 labelers

Compared with its class

The middle of its 7 NDCs’ NADAC prices is $0.11595 per EA filed.

Of the 108 other products in FDA’s Opioid Agonist class priced per EA, 105 have a higher middle NADAC price and 3 a lower one. The one in the middle is MORPHINE SULF ER 100 MG TABLET, at $0.85389 per EA filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $6.63 for 30 tablets, at an average of $0.22098 per EA in 2024 (2024-01-01 to 2024-12-31) for “Tramadol HCl-Acetaminophen” and “Tramadol HCl/Acetaminophen”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 286,567 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 30 tablets? Is it lower than what I would pay through my insurance?
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.