XHANCE 93 MCG EXHALATION DELIVERY NASAL SPRAY

What it is

XHANCE 93 MCG EXHALATION DELIVERY NASAL SPRAY is how the CMS NADAC file names this product. The FDA NDC Directory lists it as fluticasone propionate, under the trade name “XHANCE”.

FDA gives its dosage form as spray, metered and its route as nasal.

The labeler, the company named on the label, is OptiNose US, Inc.

FDA’s Established Pharmacologic Class for it is Corticosteroid.

The NADAC file of 2026-10-14 prices it under one NDC (National Drug Code), 71143-0375-01.

NADAC classes it as a brand-name drug (rate-setting class B), and does not mark it as sold over the counter.

What pharmacies pay

Pharmacies pay $40.84 for 1 mL (1 × $40.83706 per ML, rounded to the cent), by the CMS NADAC file of 2026-10-14; that price took effect on 2026-09-23. That is what pharmacies pay their suppliers, not what they charge you.

NADAC’s explanation codes for it: 1, calculated from the most recently completed pharmacy survey; 5, calculated based on package size.

What NADAC measures · NADAC explanation codes

The NDC

• 71143-0375-01 · OptiNose US, Inc. · $40.83706 per ML · eff. 2026-09-23 filed

Other strengths, forms and brands

14 other products in the NADAC file share the FDA nonproprietary name fluticasone propionate with XHANCE 93 MCG EXHALATION DELIVERY NASAL SPRAY.

Part D is one average per brand and generic name, over every strength and form.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

Medicare Part D · DSD_PTD_RY26_P04_V10_DY24_BGM.csv · eff. 2024-01-01 to 2024-12-31 · as of 2026-06-25 · retrieved 2026-10-18

Compared with its class

Its NADAC price is $40.83706 per ML filed.

Of the 106 other products in FDA’s Corticosteroid class priced per ML, 4 have a higher middle NADAC price and 102 a lower one. The one in the middle is FLUNISOLIDE 0.025% SPRAY, at $1.98777 per ML filed (eff. 2026-09-23).

Prices are compared per unit, whatever the strength or dose, and a class is not a list of substitutes.

CMS NADAC · nadac-national-average-drug-acquisition-cost-20261014.csv · eff. 2026-09-23 · as of 2026-10-14 · retrieved 2026-10-17

How the class comparison works

What Medicare paid

Medicare Part D paid $37.72 for 1 mL, at an average of $37.71589 per ML in 2024 (2024-01-01 to 2024-12-31) for “Xhance” and “Fluticasone Propionate”, every strength and form sold under that name together (Medicare Part D Spending by Drug, file of 2026-06-25).

That average covers 25,053 Part D claims (fills, including refills) for 2024-01-01 to 2024-12-31, across every maker, strength and form under the name.

Medicare's price is not your price.

What Part D spending measures · Which Medicare figure OpenBill compares · How the spread is worked out

What to ask at the counter

None of these figures is your price: what you pay depends on your pharmacy, your insurance, coupons and discounts.

• What is your cash price for 1 mL? Is it lower than what I would pay through my insurance?
• How much is in the package I am getting? This page uses 1 mL; your package may hold a different amount.
• If you have Medicare Part D: what is my plan’s copay or coinsurance for it? The Part D average on this page is not what you pay.
• These are questions about price, not medical advice. Do not change or stop a medicine without talking to your prescriber or pharmacist.